Evidence map›Paper›PMID 37471421›Full record

ArticleAmerican journal of physiology. Renal physiology2023

IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model.

Kayo Okamura, Sizhao Lu, Zhibin He, Chris Altmann, John R Montford, Amy S Li, M Scott Lucia, David J Orlicky, Mary Weiser-Evans, Sarah Faubel

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kayo OkamuraDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-9410-5038
Sizhao LuDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Zhibin HeDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-8235-300X
Chris AltmannDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
John R MontfordDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0003-4824-1922
Amy S LiDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-5304-8022
M Scott LuciaDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
David J OrlickyDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-0417-1400
Mary Weiser-EvansDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-6239-2412
Sarah FaubelDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0003-1688-6873
University of Colorado Anschutz Medical Campus · US

Funding

TRAINING IN RENAL &ELECTROLYTE DISEASE &HYPERTENSIONT32DK007135 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, RICHARD JOSEPH, KENDRICK, JESSICA B · 1986 to 2024
$5.3M
The Role of Bone Marrow Derived Eicosanoids in Renal Disease ProgressionIK2BX003839 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI MONTFORD, JOHN ROSS · 2018 to 2024
–
BLRD VA I01 BX003803BLRD VA IK2 BX003839NIDDK NIH HHS T32 DK007135
6 · The paper itself

Abstract

Prerenal azotemia (PRA) is a major cause of acute kidney injury and uncommonly studied in preclinical models. We sought to develop and characterize a novel model of PRA that meets the clinical definition: acute loss of glomerular filtration rate (GFR) that returns to baseline with resuscitation. Adult male C57BL/6J wild-type (WT) and

Indexed as

Acute Kidney InjuryAzotemiaAcute-Phase ReactionAnimalsBiomarkersDisease Models, AnimalFurosemideGlomerular Filtration RateInterleukin-6Lipocalin-2LiverMaleMiceMice, Inbred C57BLBiomarkersFurosemideInterleukin-6interleukin-6, mouseLipocalin-2acute kidney injurybiomarkersinterleukin-6NGALorgan cross talkvolume depletion

Identifiers

PMID37471421
PMCPMC10511171
OpenAlexW4384925757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.