ArticlePloS one2023
Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Current burden, incidence trends, and future projections of pancreatic cancer in adults worldwide.Journal of global health · 2026Article
- Persistence of severe global inequalities in the burden of pancreatic cancer: a cross-sectional study.Discover oncology · 2026Article
- Catching pancreatic cancer early: the promise of affordable biomarkers to regularly screen high-risk individuals.Translational gastroenterology and hepatology · 2026Article
- Bayesian mapping of mortality clusters.Biostatistics (Oxford, England) · 2025Article
- The escalating burden of osteoarthritis in East and Southeast Asia: an information-analytical study from the GBD 2021.Clinical rheumatology · 2025Observational
- Association of LAMA3 expression with perineural invasion and chemoresistance in pancreatic ductal adenocarcinoma.Discover oncology · 2025Article
- A dual self-attentive transformer U-Net model for precise pancreatic segmentation and fat fraction estimation.BMC medical imaging · 2025Article
- Article
- Burden of pancreatic cancer in Iran: an analysis of Global Burden of Disease 2021.Gastroenterology and hepatology from bed to bench · 2025Article
- Rising burden of pancreatic cancer in China: Trends, drivers, and future projections.PloS one · 2025Article
- Establishment of prediction model for mortality risk of pancreatic cancer: a retrospective study.BMC medical informatics and decision making · 2024Article
- Global spatiotemporal distributions of lymphoma from 1990 to 2019: A Joinpoint regression analysis based on the global burden of disease study 2019, and projections until 2044.Dialogues in health · 2024Article
- Trends and projections of the global burden of thyroid cancer from 1990 to 2030.Journal of global health · 2024Article
- Burden of psoriasis in young adults worldwide from the global burden of disease study 2019.Frontiers in endocrinology · 2024Article
- MicroRNAs: emerging biomarkers and therapeutic targets in pancreatic cancer.Frontiers in molecular biosciences · 2024Review
- Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment.Frontiers in nutrition · 2024Review
- From Pain to Progress: Comprehensive Analysis of Musculoskeletal Disorders Worldwide.Journal of pain research · 2024Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionPancreatic cancer (PC) is one of the most fatal malignancies, and its incidence and mortality rates are growing annually throughout the world. In this research, we aimed to investigate the time trends and identify the spatial clusters of incidence and mortality on a global scale over the last 30 years, using the Global Burden of Disease (GBD) study 2019 data.
methodsAge-standardized incidence and mortality data due to PC were extracted from the GBD study, which was carried out from 1990 to 2019. A Joinpoint regression analysis was utilized to examine trends in the incidence and mortality of PC over the past three decades. As such, spatial analyses were undertaken to detect the spatial distribution and clustering of the metrics globally.
resultsIt was observed that both the incidence and mortality rates were higher in males than in females worldwide. The global mortality and incidence rates significantly increased by 0.8% per year over the time of follow-up period (p<0.05). By spatial cluster analysis for mortality, European and North African countries, as well as Greenland were explored as hot spots; while South African and Southeast Asian countries were explored as cold spots. Regarding incidence, hot spots were found in European countries, Southern America, and Greenland; whilst cold spots were determined in Southern Africa and Madagascar.
conclusionsCollectively, the temporal trends disclosed a gradual rise in PC incidence and mortality rates over the period 1990-2019, reflecting the global health concern. We further found geographical variations in the patterns and identified high- and low-risk areas for incidence and mortality. These findings facilitate the design and implementation of more resource-efficient and geographically targeted treatments. Given the results of the current study, a practical approach to minimizing the future PC burden involves planned population-wide interventions, as well as primary prevention through healthier lifestyles.
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