Evidence map›Paper›PMID 37471227›Full record

ArticleCell reports2023

Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4

Yuan Chen, Georgina H Mason, D Oliver Scourfield, Alexander Greenshields-Watson, Tracey A Haigh, Andrew K Sewell, Heather M Long, Awen M Gallimore, Pierre Rizkallah, Bruce J MacLachlan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Pan-Variant SARS-CoV-2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. De novo design of anti-variant COVID-19 vaccine.Biology methods & protocols · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yuan ChenDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Georgina H MasonDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
D Oliver ScourfieldDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Alexander Greenshields-WatsonDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Tracey A HaighInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Andrew K SewellDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Heather M LongInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Awen M GallimoreDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Pierre RizkallahDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Bruce J MacLachlanDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: maclachlanb@cardiff.ac.uk.
Andrew GodkinDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Department of Gastroenterology & Hepatology, University Hospital of Wales, Cardiff CF14 4XW, UK. Electronic address: godkinaj@cardiff.ac.uk.
Cardiff University · GBUniversity of Birmingham · GBUniversity Hospital of Wales · GB

Funding

Department of HealthMedical Research Council MC_PC_20031Medical Research Council MC_PC_20060Medical Research Council MR/V028448/1Wellcome TrustWellcome Trust 209213/Z/17/Z
6 · The paper itself

Abstract

CD4

Indexed as

COVID-19SARS-CoV-2CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEpitopes, T-LymphocyteHLA-DR1 AntigenHumansPeptidesEpitopes, T-LymphocyteHLA-DR1 AntigenPeptidesantigen presentationCD4(+) T cellscoronavirusCOVID-19CP: ImmunologycrystallographyHLA class IIimmune escapeimmune memorySARS-CoV-2T cells

Identifiers

PMID37471227
PMCPMC10840515
OpenAlexW4384924999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.