Evidence map›Paper›PMID 37470907›Full record

ArticleNeurochemical research2023

Transforming Growth Factor β1 Ameliorates Microglial Activation in Perioperative Neurocognitive Disorders.

Dandan Lin, Yi Sun, Yuzhu Wang, Di Yang, Min Shui, Yiming Wang, Ziyi Xue, Xiao Huang, Yan Zhang, Anshi Wu and 1 more

Abstract read
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In one paragraph

Article in Neurochemical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Dandan LinDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Yi SunDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Yuzhu WangDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Di YangDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Min ShuiDepartment of Anesthesiology, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, University of Electronic Science and Technology of China, Chengdu, China.
Yiming WangState Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, 100871, China.
Ziyi XueDepartment of Anesthesiology, Peking University First Hospital, Beijing, China.
Xiao HuangDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China.
Yan Zhang *State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, 100871, China. yanzhang@pku.edu.cn.
Anshi Wu *Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China. wuanshi1965@163.com.
Changwei Wei *Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chao-Yang District, Beijing, 100020, China. changwei.wei@ccmu.edu.cn.
Capital Medical University · CNBeijing Chao-Yang Hospital · CNPeking University · CNUniversity of Electronic Science and Technology of China · CN

Funding

Beijing Chao-Yang Hospital Golden Seeds Foundation CYJZ202128Beijing Natural Science Foundation 7222074National Natural Science Foundation of China 81971679National Natural Science Foundation of China 82071176National of Science and Technology Innovation 2030 2022ZD0211800Qidong-PKU SLS Innovation Fund 2016000663
6 · The paper itself

Abstract

Perioperative neurocognitive disorder (PND) is a common complication of surgery and anesthesia, especially among older patients. Microglial activation plays a crucial role in the occurrence and development of PND and transforming growth factor beta 1 (TGF-β1) can regulate microglial homeostasis. In the present study, abdominal surgery was performed on 12-14 months-old C57BL/6 mice to establish a PND model. The expression of TGF-β1, TGF-β receptor 1, TGF-β receptor 2, and phosphor-smad2/smad3 (psmad2/smad3) was assessed after anesthesia and surgery. Additionally, we examined changes in microglial activation, morphology, and polarization, as well as neuroinflammation and dendritic spine density in the hippocampus. Behavioral tests, including the Morris water maze and open field tests, were used to examine cognitive function, exploratory locomotion, and emotions. We observed decreased TGF-β1 expression after surgery and anesthesia. Intranasally administered exogenous TGF-β1 increased psmad2/smad3 colocalization with microglia positive for ionized calcium-binding adaptor molecule 1. TGF-β1 treatment attenuated microglial activation, reduced microglial phagocytosis, and reduced surgery- and anesthesia-induced changes in microglial morphology. Compared with the surgery group, TGF-β1 treatment decreased M1 microglial polarization and increased M2 microglial polarization. Additionally, surgery- and anesthesia-induced increase in interleukin 1 beta and tumor necrosis factor-alpha levels was ameliorated by TGF-β1 treatment at postoperative day 3. TGF-β1 also ameliorated cognitive function after surgery and anesthesia as well as rescue dendritic spine loss. In conclusion, surgery and anesthesia induced decrease in TGF-β1 levels in older mice, which may contribute to PND development; however, TGF-β1 ameliorated microglial activation and cognitive dysfunction in PND mice.

Indexed as

MicrogliaTransforming Growth Factor beta1AnimalsHumansInfantMiceMice, Inbred C57BLNeurocognitive DisordersReceptors, Transforming Growth Factor betaTransforming Growth Factor betaReceptors, Transforming Growth Factor betaTransforming Growth Factor betaTransforming Growth Factor beta1microglianeuroinflammationperioperative neurocognitive disordersynapseTransforming growth factor beta 1

Identifiers

PMID37470907
OpenAlexW4384819404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.