ArticleMikrochimica acta2023
A novel fluorescent aptasensor based on 3D porous nitrogen-sulfur co-doped carbon mesh and hybridization chain reaction for sensitive detection of ochratoxin A.
Article in Mikrochimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 14 citations in OpenAlex.
- A ratiometric fluorescent aptamer assay based on RCA amplification mult-G-quadruplex.Analytical and bioanalytical chemistry · 2025Article
- Simultaneous Detection of Ochratoxin A and Aflatoxin B1 Based on Stable Tuning Fork-shaped DNA Fluorescent Aptasensor.Journal of fluorescence · 2025Article
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6 authors at 3 institutions in 1 country.
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Abstract
A novel three-dimensional (3D) porous nitrogen-sulfur co-doped carbon (N-S-C) mesh was synthesized and used for the first time as the quenching material to construct a fluorescent aptasensor for ochratoxin A (OTA) detection. The fluorescent aptasensor with enzyme-free signal amplification strategy was developed by using cDNA as a promoter to trigger hybridization chain reaction (HCR), which effectively improved the sensitivity of this aptasensor. In the absence of OTA, 3D porous N-S-C mesh can adsorb carboxyfluorescein FAM-labeled hairpin DNA1 (H1-FAM) and hairpin DNA2 (H2) and quench the fluorescence of FAM. In the presence of the OTA, the OTA specifically binds to the aptamer strand and the DNA duplex undergoes dissociation. The released cDNA in turn serves as a promoter for HCR, and the strand assembly of H1-FAM and H2 is triggered by the promoter to generate long-strand DNA polymers via HCR, resulting in an increasing fluorescent signal. Under optimal conditions, there was a good linear relationship between lgC
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