ArticleIntensive care medicine2023
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis.
Open access · greenAbstract read
In one paragraph
Article in Intensive care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies.Molecular biomedicine · 2026Review
- Correlation analysis of the expression levels of serum endothelial cell adhesion molecule-1 and sirtuin 1 protein in acute respiratory distress syndrome.Journal of medical biochemistry · 2026Article
- Repeated air pollution exposure predisposes to adverse outcomes from acute lung injury.Particle and fibre toxicology · 2026Article
- Review
- Impact of air pollution on exacerbations of respiratory and cardiovascular diseases for the intensivist: a narrative review.Intensive care medicine experimental · 2026Review
- Epidemiology of the acute respiratory distress syndrome and the prognostic validity of SpOCritical care (London, England) · 2026Article
- Long-term ozone exposure and the risk of mortality in sepsis patients in a Chinese cohort.Frontiers in public health · 2026Article
- Advanced nanotherapies for precision treatment of inflammatory lung diseases.Bioactive materials · 2025Review
- Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange.Critical care explorations · 2025Article
- Temporal stability of phenotypes of acute respiratory distress syndrome: clinical implications for early corticosteroid therapy and mortality.Intensive care medicine · 2025Article
- Identifying a unique signature of sepsis in patients with pre-existing cirrhosis.Critical care (London, England) · 2025Article
- Predicting mortality and risk factors of sepsis related ARDS using machine learning models.Scientific reports · 2025Article
- Air pollutant exposure and mortality risk of critically ill patients.Intensive care medicine · 2025Article
- Environmental Risk Factors for Acute Respiratory Distress Syndrome.Clinics in chest medicine · 2024Review
- Further Insight into the Association of Long-Term Particulate Matter Exposure and Mortality in Hospitalized Patients with COVID-19.Annals of the American Thoracic Society · 2024Article
- Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Long-Term Particulate Matter Exposure and Mortality in Hospitalized Patients with COVID-19 in South Korea.Annals of the American Thoracic Society · 2024Article
- Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.American journal of respiratory and critical care medicine · 2024Article
- Effects of ambient air pollutants on ARDS incidence and outcome: a narrative review.Annals of intensive care · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
John P ReillyDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA. john.reilly@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-3937-5320
Zhiguo ZhaoDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA.
Michael G S ShashatyDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Tatsuki KoyamaDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA.
Tiffanie K JonesDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Brian J AndersonDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Caroline A IttnerDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Thomas DunnDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Todd A MianoCenter for Clinical Epidemiology and Biostatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA.
Oluwatosin OniyideDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
John R BalmesDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA.
Michael A MatthayDepartment of Medicine, University of California, San Francisco, USA.
Carolyn S CalfeeDepartment of Medicine, University of California, San Francisco, USA.
Jason D ChristieDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Nuala J MeyerDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Perelman School of Medicine, 5005 Gibson Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Lorraine B WareDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, USA.
University of Pennsylvania · USUniversity of California, San Francisco · USVanderbilt University · USTranslational Therapeutics (United States) · US
Funding
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3MPrecision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8MInvestigating Individual Susceptibility and Host Response in Acute Respiratory Distress SyndromeR35HL161196 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Nuala Jennings Meyer · 2022 to 2026
$4.8MAn ABO Blood Type Defined ARDS Endotype in SepsisR01HL155159 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI REILLY, JOHN PATRICK · 2021 to 2025
$2.7MHaptoglobin 2 variant and endothelial glycocalyx shedding in sepsis-induced ARDSR01HL158906 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2021 to 2024
$2.3MReconsidering the IL-1 axis in sepsis-associated ARDSR01HL137915 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2017 to 2020
$2.1MMidcareer Investigator Award in Patient-Oriented Research in Acute Lung InjuryK24HL103836 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2010 to 2020
$1.6MNeurocognitive Impairment in Acute Respiratory Failure and Shock: Understanding the Role of Neuronal ExcitotoxicityK23HL140482 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ANDERSON, BRIAN J. · 2018 to 2022
$959kThe Role of ABO Glycosyltransferases in the Acute Respiratory Distress SyndromeK23HL125723 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI REILLY, JOHN PATRICK · 2015 to 2019
$840kMentoring Patient-Oriented Research to Promote ARDS Precision MedicineK24HL155804 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2021 to 2021
$124kMESO QuikPlex SQ 120 for the multiplex quantification of proteins in human biospecimensS10OD025172 · OD · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 2018 to 2018
$50kNHLBI NIH HHS K23 HL125723NHLBI NIH HHS K23 HL140482NHLBI NIH HHS K24 HL103836NHLBI NIH HHS K24 HL155804NHLBI NIH HHS R01 HL137915NHLBI NIH HHS R01 HL155159NHLBI NIH HHS R01 HL158906NHLBI NIH HHS R35 HL140026NHLBI NIH HHS R35 HL161196NIEHS NIH HHS P30 ES013508NIH HHS S10 OD025172NIOSH CDC HHS T42 OH008429ODCDC CDC HHS S10 OD025172
Abstract
purposeExposures to ambient air pollutants may prime the lung enhancing risk of acute respiratory distress syndrome (ARDS) in sepsis. Our objective was to determine the association of short-, medium-, and long-term pollutant exposures and ARDS risk in critically ill sepsis patients.
methodsWe analyzed a prospective cohort of 1858 critically ill patients with sepsis, and estimated short- (3 days), medium- (6 weeks), and long- (5 years) term exposures to ozone, nitrogen dioxide (NO
resultsARDS developed in 754 (41%) subjects. Short- and long-term exposures to SO
conclusionShort and long-term exposures to ambient SO
Indexed as
Air PollutantsAir PollutionEnvironmental PollutantsRespiratory Distress SyndromeSepsisCritical IllnessHumansNitrogen DioxideParticulate MatterProspective StudiesAir PollutantsEnvironmental PollutantsNitrogen DioxideParticulate MatterAcute lung injuryAcute respiratory distress syndromeAir pollutionSepsis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.