Evidence map›Paper›PMID 37470704›Full record

ArticleeLife2023

Inhibition of DNMT1 methyltransferase activity via glucose-regulated

Heon Shin, Amy Leung, Kevin R Costello, Parijat Senapati, Hiroyuki Kato, Roger E Moore, Michael Lee, Dimitri Lin, Xiaofang Tang, Patrick Pirrotte and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. CanPharmaceuticals (Basel, Switzerland) · 2024
    Review
  12. Epigenomic insights into common human disease pathology.Cellular and molecular life sciences : CMLS · 2024
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Heon ShinDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.ORCID 0000-0001-5480-8492
Amy LeungDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.
Kevin R CostelloDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.
Parijat SenapatiDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.ORCID 0000-0002-7324-1230
Hiroyuki KatoDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.
Roger E MooreIntegrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center Duarte, Duarte, United States.
Michael LeeDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.
Dimitri LinDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.
Xiaofang TangDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.
Patrick PirrotteDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.
Zhen Bouman ChenDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.ORCID 0000-0002-3291-1090
Dustin E SchonesDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, United States.ORCID 0000-0001-7692-8583
City of Hope · USTranslational Genomics Research Institute · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Epigenetic damage in women living in LA food-desert zip codesR01CA220693 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K., HYSLOP, TERRY · 2017 to 2021
$3.7M
Epigenetic dysregulation of transposons in obesityR01DK112041 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SCHONES, DUSTIN EDWARD · 2017 to 2021
$2.2M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA220693NIDDK NIH HHS R01 DK112041NIH HHS R01CA220693NIH HHS R01DK112041
6 · The paper itself

Abstract

The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by

Indexed as

GlucoseHyperglycemiaAnimalsDNA (Cytosine-5-)-Methyltransferase 1DNA MethylationEpigenomeGlycosylationHumansMiceDNA (Cytosine-5-)-Methyltransferase 1Glucosechromosomesepigeneticsgene expressionhumanhyperglycemiametabolismmus musculusO-GlcNAcylation

Identifiers

PMID37470704
PMCPMC10390045
OpenAlexW4384819041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.