ArticleJournal of enzyme inhibition and medicinal chemistry2023
α-Glucosidase inhibition by green, white and oolong teas:
Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Enhancement of Gluten Quality and Rheology in Sunn Pest (Eurygaster spp.)-Damaged Wheat Flour Using Plant Extracts.Journal of food science · 2026Article
- Optimized Isolation of White Tea Infusion Micro-Nanoparticles and Stability Mechanism: A Composition-Structure-Stability Perspective.Foods (Basel, Switzerland) · 2026Article
- Design, synthesis, biological evaluation, andRSC advances · 2026Article
- Green-synthesized silver nanoparticles from Camellia sinensis: mechanistic insights into phenolic-mediated multifunctional biological activities.BMC plant biology · 2025Article
- Exploring Small-Molecule Inhibitors of Glucosidase II: Advances, Challenges, and Therapeutic Potential in Cancer and Viral Infection.International journal of molecular sciences · 2025Review
- Suppressed Autoxidation, Enhanced Antioxidant Activity, and Improved Cytocompatibility of Epigallocatechin Gallate via Alginate Site-Specific Conjugation with Tunable Substitution Degree.International journal of molecular sciences · 2025Article
- Tea Consumption and Diabetes: A Comprehensive Pharmacological Review of Black, White, Green, Oolong, and Pu-erh Teas.Plants (Basel, Switzerland) · 2025Review
- Hierarchical mesoporous ZIF-8-immobilized enzyme microreactor coupled with HPLC for screening of α-glucosidase inhibitors from green tea.Mikrochimica acta · 2025Article
- The role of tea in managing cardiovascular risk factors: potential benefits, mechanisms, and interventional strategies.Frontiers in nutrition · 2025Review
- Profiling of Potential Anti-Diabetic Active Compounds in White Tea: An Integrated Study of Polyphenol-Targeted Metabolomics, Network Pharmacology, and Computer Simulation.Foods (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural α-glucosidase inhibitors from plant-based foods such as catechins offer an attractive strategy for their potential anti-diabetic effects. In this study, infusions of three different tea types (green, white, and oolong) were investigated for their total phenolic (TPC) and catechins (EGCG, ECG, EGC, and EC) content, and for their α-glucosidase inhibitory activities. We observed that the level of TPC in white tea was significantly higher compared to oolong and green tea, which suggests higher content of EGCG and ECG catechins in fresh young leaves. Our findings showed that the higher content of such catechins in the infusion of white tea well correlated with a strong inhibition of α-glucosidase, and such inhibition was demonstrated to be more effective than the FDA-approved drug acarbose. Then, we computationally explored the molecular requirements for enzyme inhibition, especially for the most active catechins EGCG and ECG, as well as their disposition/stability within the active site.
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Registered trials
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