Evidence map›Paper›PMID 37470161›Full record

ArticleStroke2023

Sleep Duration Is Associated With Subclinical Carotid Plaque Burden.

Christian Agudelo, Alberto R Ramos, Hannah Gardener, Ken Cheung, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek

Open access · bronzeAbstract read
In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Sleep and Risk for Heart Disease and Stroke.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Prestroke sleep and stroke: a narrative review.Sleep & breathing = Schlaf & Atmung · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Christian AgudeloDepartment of Neurology (C.A., A.R.R., H.G., R.L.S., T.R.), University of Miami Miller School of Medicine, FL.ORCID 0000-0001-8957-8615
Alberto R RamosDepartment of Neurology (C.A., A.R.R., H.G., R.L.S., T.R.), University of Miami Miller School of Medicine, FL.ORCID 0000-0002-9861-6609
Hannah GardenerDepartment of Neurology (C.A., A.R.R., H.G., R.L.S., T.R.), University of Miami Miller School of Medicine, FL.ORCID 0000-0003-1416-632X
Ken CheungDepartment of Biostatistics (K.C.), Mailman School of Public Health, Columbia University, NY.ORCID 0000-0001-8530-035X
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, NY.ORCID 0000-0003-2562-1156
Ralph L SaccoDepartment of Neurology (C.A., A.R.R., H.G., R.L.S., T.R.), University of Miami Miller School of Medicine, FL.ORCID 0000-0003-4629-684X
Tatjana RundekDepartment of Neurology (C.A., A.R.R., H.G., R.L.S., T.R.), University of Miami Miller School of Medicine, FL.ORCID 0000-0002-7115-9815
University of Miami · USChapman University · USColumbia University · US

Funding

Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)R01AG067568 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Alberto Rafael Ramos · 2021 to 2026
$13.7M
Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
NIA NIH HHS L30 AG074434NIA NIH HHS R01 AG067568NINDS NIH HHS R37 NS029993
6 · The paper itself

Abstract

backgroundSleep duration is associated with stroke risk and is 1 of 8 essential components of cardiovascular health according to the American Heart Association. As stroke disproportionately burdens Black and Hispanic populations in the United States, we hypothesized that long and short sleep duration would be associated with greater subclinical carotid atherosclerosis, a precursor of stroke, in the racially and ethnically diverse NOMAS (Northern Manhattan Study).

methodsNOMAS is a study of community-dwelling adults. Self-reported nightly sleep duration and daytime sleepiness were collected between 2006 and 2011. Carotid plaque presence, total plaque area, and intima-media thickness were measured by ultrasound between 1999 and 2008. Linear and logistic regression models examined the cross-sectional associations of sleep duration groups (primary exposure) or daytime sleepiness (secondary exposure) with measures of carotid atherosclerosis. Models adjusted for age, time between ultrasound and sleep data collection, sex, race and ethnicity, education, health insurance, smoking, alcohol use, physical activity, body mass index, hypertension, diabetes, hypercholesterolemia, and cardiac disease.

resultsThe sample (n=1553) had a mean age of 64.7±8.5 years and was 61.9% female, 64.8% Hispanic, and 18.2% non-Hispanic Black. Of the sample, 55.6% had carotid plaque, 22.3% reported nightly short sleep (<7 hours), 66.6% intermediate sleep (≥7 and <9 hours), and 11.1% had long sleep (≥9 hours). Compared with intermediate sleep, long sleep was associated with greater odds of carotid plaque presence relative to plaque absence (odds ratio, 1.6 [95% CI, 1.1-2.4]) and larger total plaque area (odds ratio, 1.4 [95% CI, 1.0-1.9]) after full covariate adjustment. Short sleep and daytime sleepiness were not significantly associated with any carotid measures.

conclusionsThe association between long sleep and subclinical carotid atherosclerosis may explain prior associations between long sleep and stroke.

Indexed as

Carotid Artery DiseasesDisorders of Excessive SomnolenceNomaPlaque, AtheroscleroticStrokeAdultAgedCarotid Intima-Media ThicknessCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsSleep DurationUnited StatesAmerican Heart Associationatherosclerosisrisk factorssleepstroke

Identifiers

PMID37470161
PMCPMC10527503
OpenAlexW4384819964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.