Evidence map›Paper›PMID 37470035›Full record

ArticleFrontiers in genetics2023

Myeloid lineage cells evince distinct steady-state level of certain gene groups in dependence on hereditary angioedema severity.

Lucie Ballonová, Přemysl Souček, Peter Slanina, Kamila Réblová, Ondřej Zapletal, Marcela Vlková, Roman Hakl, Viktor Bíly, Hana Grombiříková, Eliška Svobodová and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Lucie BallonováCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Přemysl SoučekCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Peter SlaninaFaculty of Medicine, Masaryk University, Brno, Czechia.
Kamila RéblováCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Ondřej ZapletalCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Marcela VlkováFaculty of Medicine, Masaryk University, Brno, Czechia.
Roman HaklFaculty of Medicine, Masaryk University, Brno, Czechia.
Viktor BílyCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Hana GrombiříkováCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Eliška SvobodováCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Petra KulíškováCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Julie ŠtíchováFaculty of Medicine, Masaryk University, Brno, Czechia.
Marta SobotkováDepartment of Immunology, Second Medical School Charles University and University Hospital Motol, Brno, Czechia.
Radana ZachováDepartment of Immunology, Second Medical School Charles University and University Hospital Motol, Brno, Czechia.
Jana HanzlíkováDepartment of Immunology and Allergology, University Hospital Pilsen, Pilsen, Czechia.
Martina VachováDepartment of Immunology and Allergology, University Hospital Pilsen, Pilsen, Czechia.
Pavlína KrálíčkováInstitute of Clinical Immunology and Allergy, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czechia.
Irena KrčmováInstitute of Clinical Immunology and Allergy, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czechia.
Miloš JeseňákNational Centre for Hereditary Angioedema, Department of Pediatrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovakia.
Tomáš FreibergerCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Centrum kardiovaskulární a transplantační chirurgie · CZMasaryk University · CZCharles University · CZCentral European Institute of Technology – Masaryk University · CZComenius University Bratislava · SKUniversity Hospital in Motol · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary angioedema (HAE) is a rare genetic disorder with variable expressivity even in carriers of the same underlying genetic defect, suggesting other genetic and epigenetic factors participate in modifying HAE severity. Recent knowledge indicates the role of immune cells in several aspects of HAE pathogenesis, which makes monocytes and macrophages candidates to mediate these effects. Here we combined a search for HAE phenotype modifying gene variants with the characterization of selected genes' mRNA levels in monocyte and macrophages in a symptom-free period. While no such gene variant was found to be associated with a more severe or milder disease, patients revealed a higher number of dysregulated genes and their expression profile was significantly altered, which was typically manifested by changes in individual gene expression or by strengthened or weakened relations in mutually co-expressed gene groups, depending on HAE severity.

Indexed as

FXIIgene expressionhereditary angioedemaimmune cellinterferon-gamma

Identifiers

PMID37470035
PMCPMC10352584
OpenAlexW4383105386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.