Evidence map›Paper›PMID 37469877›Full record

ArticleFrontiers in pharmacology2023

Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy.

Keith M Olson, Andrea L Devereaux, Payal Chatterjee, Savanah L Saldaña-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D MacKerell, John R Traynor, Christopher W Cunningham

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keith M OlsonDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States.
Andrea L DevereauxDepartment of Pharmaceutical Sciences, Concordia University Wisconsin School of Pharmacy, Mequon, WI, United States.
Payal ChatterjeeDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States.
Savanah L Saldaña-ShumakerDepartment of Pharmaceutical Sciences, Concordia University Wisconsin School of Pharmacy, Mequon, WI, United States.
Amanda ShaferDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States.
Adam PlotkinDepartment of Pharmaceutical Sciences, Concordia University Wisconsin School of Pharmacy, Mequon, WI, United States.
Ram KandasamyDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States.
Alexander D MacKerellDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States.
John R TraynorDepartment of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States.
Christopher W CunninghamDepartment of Pharmaceutical Sciences, Concordia University Wisconsin School of Pharmacy, Mequon, WI, United States.

Funding

POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
Allosteric Modulation of the Mu-Opioid ReceptorR37DA039997 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 2015 to 2024
$6.4M
Macromolecular Conformational HeterogeneityR35GM131710 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ALEXANDER D MACKERELL · 2019 to 2026
$6.2M
NIDA NIH HHS R37 DA039997NIDA NIH HHS T32 DA007268NIGMS NIH HHS R35 GM131710
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bifunctional analgesicsdelta opioid receptordependencemu opioid receptorSILCStolerance

Identifiers

PMID37469877
PMCPMC10352325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.