Evidence map›Paper›PMID 37469808›Full record

ReviewCureus2023

The Use of Empagliflozin Post Myocardial Infarction.

Kapilraj Ravendran, Nikolaos Madouros, Edzhem Yoztyurk, Aishwarya Wilson, Maria J Jeejo, Monica E Camelio, Akatya Sinha, Ananya George, Mriganka Rai, Hussain K Malik

Open access · diamondAbstract readReview
In one paragraph

Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Kapilraj RavendranGeneral Surgery, East Sussex Healthcare NHS Trust, Brighton and Hove, GBR.
Nikolaos MadourosSurgery Working Group, Society of Junior Doctors, Athens, GRC.
Edzhem YoztyurkInternal Medicine, Medical University of Sofia, Sofia, BGR.
Aishwarya WilsonInternal Medicine, Medical University of Sofia, Sofia, BGR.
Maria J JeejoInternal Medicine, Medical University of Sofia, Sofia, BGR.
Monica E CamelioVascular Surgery, St George's University Hospital, London, GBR.
Akatya SinhaMedicine, MGM (Mahatma Gandhi Mission) Medical College, Mumbai, IND.
Ananya GeorgeGastroenterology, Norfolk and Norwich University Hospital, Norwich, GBR.
Mriganka RaiInternal Medicine, Medical University of Sofia, Sofia, BGR.
Hussain K MalikInternal Medicine, Medical University of Sofia, Sofia, BGR.
Mahatma Gandhi Memorial Medical College · INMedical University of Sofia · BGSt George's Hospital · GBDoctors Hospital · USEast Sussex Healthcare NHS Trust · GBMahatma Gandhi Mission Medical College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is mainly used for the treatment of type 2 diabetes mellitus. The study's objective was to assess empagliflozin's effects and impacts on post-myocardial patients to highlight its worth in comparison to alternative therapies. Only studies evaluating the effects of empagliflozin on individuals who have undergone a myocardial infarction (MI) are included in this review of the literature, which employed PubMed, Google Scholar, and Embase. To compare the advantages of empagliflozin for individuals who have recently experienced a myocardial infarction, abstracts from pertinent articles were retrieved, and complete publications were reviewed. A total of four articles were reviewed, which showed that in patients who suffered from a recent MI, empagliflozin caused a significant decrease in N-terminal pro-brain natriuretic peptide (NT-proBNP). Additionally, it was shown that these individuals had better echocardiographic results for both structural and functional metrics. With studies showing a significantly larger median NT-proBNP decrease with empagliflozin compared to placebo among patients hospitalised with an acute big MI when empagliflozin was started early and administered in addition to the post-MI care suggested by guidelines, it is safe to say that the benefits outweigh the risks. There are currently larger double-blind trials in progress to prove the hypothesis of the benefits of empagliflozin for post-MI patients.

Indexed as

diabetesempagliflozinleft ventricular ejection fractionlvef (left ventricular ejection fraction)myocardial infarctionsodium-glucose cotransporter-2sodium-glucose cotransporter-2 (sglt-2) inhibitors

Identifiers

PMID37469808
PMCPMC10353858
OpenAlexW4381137224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.