Evidence map›Paper›PMID 37469663›Full record

ArticleFrontiers in medicine2023

Delayed MSC therapy enhances resolution of organized pneumonia induced by antibiotic resistant

Declan Byrnes, Claire Masterson, Jack Brady, Shahd Horie, Sean D McCarthy, Hector Gonzalez, Daniel O'Toole, John Laffey

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Declan ByrnesAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
Claire MastersonAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
Jack BradyAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
Shahd HorieAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
Sean D McCarthyAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
Hector GonzalezAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
Daniel O'TooleAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
John LaffeyAnaesthesia, School of Medicine, Clinical Sciences Institute, University of Galway, Galway, Ireland.
Ollscoil na Gaillimhe – University of Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Mesenchymal stromal cells (MSC) are a promising therapeutic for pneumonia-induced sepsis. Here we sought to determine the efficacy of delayed administration of naïve and activated bone marrow (BM), adipose (AD), and umbilical cord (UC) derived MSCs in organized antibiotic resistant Methods: Human BM-, AD-, and UC-MSCs were isolated and expanded and used either in the naïve state or following cytokine pre-activation. The effect of MSC tissue source and activation status was assessed first Results: BM-, AD-, and UC-MSCs accelerated epithelial healing, increased phagocytosis, and reduced ROS-induced epithelial injury Discussion: Delayed MSC therapy enhanced resolution of lung injury induced by antibiotic resistant

Indexed as

fibrosisimmune tolerancemesenchymal stromal cellsperipheral blood mononuclear cellspneumoniarodent animal modelssepsis

Identifiers

PMID37469663
PMCPMC10352103
OpenAlexW4382987595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.