Evidence map›Paper›PMID 37469456›Full record

ArticleFrontiers in toxicology2023

Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies.

Noelia Perez-Diaz, Ewelina Hoffman, Julie Clements, Rebecca Cruickshank, Ann Doherty, Daniel Ebner, Joanne Elloway, Jianan Fu, Joanne Kelsall, Val Millar and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Animal product-free formation and cultivation of three-dimensional primary hepatocyte spheroids.Drug metabolism and disposition: the biological fate of chemicals · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Noelia Perez-DiazImmuONE Limited, Hatfield, United Kingdom.
Ewelina HoffmanImmuONE Limited, Hatfield, United Kingdom.
Julie ClementsLabCorp Drug Development, Harrogate, United Kingdom.
Rebecca CruickshankPAN-Biotech UK Ltd., Wimborne, United Kingdom.
Ann DohertySafety Sciences, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, United Kingdom.
Daniel EbnerNuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.
Joanne EllowaySafety Sciences, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, United Kingdom.
Jianan FuPAN-Biotech GmbH, Aidenbach, Germany.
Joanne KelsallLabCorp Drug Development, Harrogate, United Kingdom.
Val MillarNuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom.
Ouarda SaibSafety and Environmental Assurance Centre (SEAC), Unilever, Bedford, United Kingdom.
Andrew ScottSafety and Environmental Assurance Centre (SEAC), Unilever, Bedford, United Kingdom.
Ian WoodsLabCorp Drug Development, Huntington, United Kingdom.
Victoria HutterImmuONE Limited, Hatfield, United Kingdom.
AstraZeneca (United Kingdom) · GBUnilever (United Kingdom) · GBUniversity of Oxford · GBUniversity of Hertfordshire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chemically defined serum replacementFBS replacementfetal bovine serumOECDsequential adaptationserum-freeTG 487TK6

Identifiers

PMID37469456
PMCPMC10353604
OpenAlexW4383066049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.