Evidence map›Paper›PMID 37469437›Full record

ArticleFrontiers in microbiology2023

Host-pathogen relationship in retreated tuberculosis with major rifampicin resistance-conferring mutations.

Nguyen Thi Le Hang, Minako Hijikata, Shinji Maeda, Pham Huu Thuong, Hoang Van Huan, Nguyen Phuong Hoang, Do Bang Tam, Pham Thu Anh, Nguyen Thu Huyen, Vu Cao Cuong and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Nguyen Thi Le HangNCGM-BMH Medical Collaboration Center, Hanoi, Vietnam.
Minako HijikataDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, JATA, Tokyo, Japan.
Shinji MaedaFaculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, Japan.
Pham Huu ThuongMy Duc District General Hospital, Hanoi, Vietnam.
Hoang Van HuanHanoi Lung Hospital, Hanoi, Vietnam.
Nguyen Phuong HoangDepartment of Microbiology, Hanoi Lung Hospital, Hanoi, Vietnam.
Do Bang TamDepartment of Biochemistry, Hematology and Blood Transfusion, Hanoi Lung Hospital, Hanoi, Vietnam.
Pham Thu AnhTuberculosis Network Management Office, Hanoi Lung Hospital, Hanoi, Vietnam.
Nguyen Thu HuyenNCGM-BMH Medical Collaboration Center, Hanoi, Vietnam.
Vu Cao CuongHanoi Department of Health, Hanoi, Vietnam.
Nobuyuki KobayashiDepartment of Internal Medicine, Fureai Machida Hospital, Tokyo, Japan.
Keiko WakabayashiDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, JATA, Tokyo, Japan.
Akiko MiyabayashiDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, JATA, Tokyo, Japan.
Shintaro SetoDepartment of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, JATA, Tokyo, Japan.
Naoto KeichoThe Research Institute of Tuberculosis, JATA, Tokyo, Japan.
Hanoi Lung Hospital · VNJapan Anti Tuberculosis Association · JPVietnamese - German Center of Excellence in Medical Research · VNHanoi School Of Public Health · VNHokkaido University of Science · JPNational Center for Global Health and Medicine · JPViet Duc Hospital · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: It is assumed that host defense systems eliminating the pathogen and regulating tissue damage make a strong impact on the outcome of tuberculosis (TB) disease and that these processes are affected by rifampicin (RIF) resistance-conferring mutations of Methods: Demographic data were collected from 295 active pulmonary TB patients with treatment history in Hanoi, Vietnam. When recruited, drug resistance-conferring mutations and lineage-specific variations were identified using whole-genome sequencing of clinical Mtb isolates. Before starting retreatment, total RNA was extracted from the whole blood of HIV-negative patients infected with Mtb that carried either the Results: In our cohort, Discussion: Our study results showed that

Indexed as

blood transcriptomic signaturesinterferon-inducible genesMycobacterium tuberculosisrecurrencerifampicin resistancerpoB variantswhole genome sequencing

Identifiers

PMID37469437
PMCPMC10352910
OpenAlexW4383104989

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.