ArticleFrontiers in psychiatry2023
Serum alkaline phosphatase was independently associated with depression in patients with cerebrovascular disease.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Magnetic Resonance Imaging in Cerebral Small Vessel Disease-Related Depression: From Visual Scoring to Artificial Intelligence.CNS neuroscience & therapeutics · 2026Review
- Serum cystatin C levels are independently correlated with cognitive impairment in individuals with cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- A Clinical Risk Prediction Model for Depressive Disorders Based on Seven Machine Learning Algorithms.International journal of general medicine · 2025Article
- Analysis of risk factors for depression in peritoneal dialysis patients and establishment of a risk nomogram model.Clinics (Sao Paulo, Brazil) · 2025Article
- Association between depression and liver function biomarkers among US cancer survivors in NHANES 2005-2020.Scientific reports · 2024Article
- Alkaline phosphatase is associated with vascular depression in patients with severe white matter hyperintensities.Frontiers in neuroscience · 2024Article
- Factors influencing accelerated aging in patients with type 2 diabetes mellitus and coronary heart disease.Frontiers in endocrinology · 2024Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Blood markers have important value in the diagnosis of depressive disorders. Serum alkaline phosphatase (ALP) not only predicts stroke recurrence and poor functional prognosis in cerebrovascular disease (CVD) patients but also increases significantly in middle-aged women with depression. Thus, it has not been reported whether serum ALP is associated with the development of depression and/or vascular depression (VDe) in CVD patients. Methods: This was a cross-sectional study of 353 CVD patients (stroke patients, Results: (1) Serum ALP ( Conclusion: Hb, hs-CRP, ChE, ALP, and HDL-C concentrations are potential blood markers of depression in CVD patients and, when combined, may improve diagnostic performance for VDe. Serum ALP was independently associated with VDe in patients with CVD.
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