ArticleMovement disorders : official journal of the Movement Disorder Society2023
X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease.
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Article in Movement disorders : official journal of the Movement Disorder Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15citing papers in PubMed, 1 pooled it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review.Neurogenetics · 2025Pooled it
- Insights into X-Linked Susceptibility to Parkinson's Disease in the South African Population.medRxiv : the preprint server for health sciences · 2025Article
- Genetic Analysis of the X Chromosome Associates Loci with Progression of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment.The Journal of clinical investigation · 2025Review
- Chromosome X-wide common variant association study in autism spectrum disorder.American journal of human genetics · 2025Article
- Genome-wide association study and transcriptomic analysis reveal the crucial role ofFrontiers in immunology · 2025Article
- X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome.Frontiers in genetics · 2025Review
- Chromosome X-Wide Common Variant Association Study (XWAS) in Autism Spectrum Disorder.medRxiv : the preprint server for health sciences · 2024Article
- Epidemiology of Parkinson's Disease: An Update.Current neurology and neuroscience reports · 2024Review
- Comparing the effect of imputation reference panel composition in four distinct Latin American cohorts.bioRxiv : the preprint server for biology · 2024Article
- Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci.NPJ Parkinson's disease · 2024Article
- Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2024 Update.Journal of Parkinson's disease · 2024Review
- Leveraging sex-genetic interactions to understand brain disorders: recent advances and current gaps.Brain communications · 2024Review
- X-chromosome variants and PD in Latin America.Nature reviews. Neurology · 2023Article
- Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation.Frontiers in immunology · 2023Review
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Authors and funding
50 authors at 20 institutions in 6 countries.
Thiago P LealLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-5829-6452
Shilpa C RaoThe Parkinson's Foundation, Miami, Florida, USA.
Jennifer N French-KwawuInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Mateus H GouveiaCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Victor BordaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sara Bandres-CigaCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-0056-1361
Miguel Inca-MartinezLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Emily A MasonUniversity of South Carolina School of Medicine, Columbia, South Carolina, USA.
Andrea R V R HorimotoDivision of Aging, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Douglas P LoeschInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Elif I SarihanLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Mario R Cornejo-OlivasNeurogenetics Working Group, Universidad Científica del Sur, Lima, Peru.ORCID 0000-0001-6313-5680
Luis E TorresMovement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Pilar E Mazzetti-SolerNeurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Carlos CosentinoMovement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.ORCID 0000-0003-3677-9856
Elison H Sarapura-CastroNeurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.ORCID 0000-0002-1562-3062
Andrea Rivera-ValdiviaNeurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Angel C MedinaUniversidad Nacional del Altiplano, Puno, Peru.
Elena M DieguezNeurology Institute, Universidad de la República, Montevideo, Uruguay.
Víctor E RaggioDepartment of Genetics, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Andrés LescanoNeurology Institute, Universidad de la República, Montevideo, Uruguay.
Vitor TumasRibeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil.
Vanderci BorgesMovement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Henrique B FerrazMovement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Carlos R RiederDepartamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
Artur Schumacher SchuhServiço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.ORCID 0000-0002-8722-0908
Bruno L Santos-LobatoInstituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil.ORCID 0000-0001-9321-5710
Carlos Velez-PardoNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
Marlene Jimenez-Del-RioNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
Francisco LoperaNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
Sonia MorenoNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
Pedro Chana-CuevasCETRAM, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile.
William FernandezNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Gonzalo ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Humberto ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Carlos E Arboleda BustosNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Dora YearoutVeterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.
Maira T BarbosaBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Francisco E C CardosoMovement Disorders Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Paulo CaramelliBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Mauro C Q CunninghamBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Débora P MaiaMovement Disorders Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Maria F Lima-CostaInstituto René Rachou da Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
Eduardo Tarazona-SantosDepartment of Genetics, Ecology and Evolution, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Cyrus P ZabetianVeterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.ORCID 0000-0002-7739-4306
International Parkinson Disease Genomics Consortium (IPDGC)
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Timothy D O'ConnorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Ignacio F MataLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD)
Universidade Federal de Minas Gerais · BRCleveland Clinic Lerner College of Medicine · USUniversidad de Antioquia · COUniversidad Nacional de Colombia · COUniversity of Maryland, Baltimore · USUniversidad de la República de Uruguay · UYUniversity of Washington · USInstitute of Peruvian Studies · PEInstituto Nacional de Ciencias NeurológicasNational Institutes of Health · USUniversidade Federal de São Paulo · BRBrigham and Women's Hospital · USFundação Oswaldo Cruz · BRNational University of San Marcos · PEParkinson's Foundation · USUniversidad Científica del Sur · PEUniversidad de Santiago de Chile · CLUniversidade de Ribeirão Preto · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal do Pará · BR
Funding
iPSC Neurodegenerative Diseasses InitiativeZIAAG000535 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2019 to 2025
$48.2MNPGH LEADERs YR12: OBSSR (Greenberg, Ngwafong Mukere) & NIBIB (Lee)D43TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI Dibyadyuti Datta, Chandy C. John · 2017 to 2026
$15.2MGenome wide SNP analysis in Parkinson's diseaseZIAAG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$12.6MVascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7MRESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2MModeling the impact of Women's Specific Health Factors in PD outcomes in LatinasR01NS112499 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FERNANDEZ MATA, IGNACIO · 2020 to 2024
$3.3MGenome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6MRapid Evolution of Genomic Architecture and Multi-omics TraitsR35HG010692 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI O'CONNOR, TIMOTHY DAVID · 2019 to 2023
$2.3MMIDCAREER AWARD IN PATIENT ORIENTED RESEARCH ON AGINGK24AG000949 · NIA · YALE UNIVERSITY · PI INOUYE, SHARON K. · 1999 to 2009
$1.4MFIC NIH HHS D43 TW009345Intramural NIH HHS Z01 AG000949Intramural NIH HHS ZIA AG000535Intramural NIH HHS ZIA AG000949NHGRI NIH HHS R35 HG010692NHLBI NIH HHS T32 HL007698NIA NIH HHS K24 AG000949NIA NIH HHS T32 AG000262NINDS NIH HHS R01 NS112499
Abstract
backgroundSex differences in Parkinson's disease (PD) risk are well-known. However, the role of sex chromosomes in the development and progression of PD is still unclear.
objectiveThe objective of this study was to perform the first X-chromosome-wide association study for PD risk in a Latin American cohort.
methodsWe used data from three admixed cohorts: (1) Latin American Research consortium on the Genetics of Parkinson's Disease (n = 1504) as discover cohort, and (2) Latino cohort from International Parkinson Disease Genomics Consortium (n = 155) and (3) Bambui Aging cohort (n = 1442) as replication cohorts. We also developed an X-chromosome framework specifically designed for admixed populations.
resultsWe identified eight linkage disequilibrium regions associated with PD. We replicated one of these regions (top variant rs525496; discovery odds ratio [95% confidence interval]: 0.60 [0.478-0.77], P = 3.13 × 10
conclusionsOur results reinforce the importance of including X-chromosome and diverse populations in genetic studies. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Indexed as
Chromosomes, Human, XParkinson DiseaseFemaleGenome-Wide Association StudyHispanic or LatinoHumansLatin AmericaLinkage DisequilibriumMaleSex Factorsadmixed populationshipanic/latinoParkinson's diseaseunderrepresented populationsx-chromosome wide association study
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