Evidence map›Paper›PMID 37469184›Full record

ArticleTechnology in cancer research & treatment

X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer.

Gayatri Sharma, Mir Hadi Razeghi Kondelaji, Guru P Sharma, Christopher Hansen, Abdul K Parchur, Shayan Shafiee, Jaidip M Jagtap, Brian Fish, Carmen Bergom, Eric Paulson and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Gayatri SharmaCentre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.
Mir Hadi Razeghi KondelajiDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.
Guru P SharmaDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Christopher HansenDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-2248-4646
Abdul K ParchurDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-2417-9848
Shayan ShafieeDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.
Jaidip M JagtapDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Brian FishDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Carmen BergomDepartment of Radiation Oncology, Washington University, St Louis, MO, USA.
Eric PaulsonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
William A HallDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Heather A HimburgDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Amit JoshiDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-7590-2522
Medical College of Wisconsin · USAmity University · INMayo Clinic in Arizona · USWashington University in St. Louis · US

Funding

Leveraging genetic mapping for personalized targeting of breast cancer microenvironmentR01CA193343 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amit Joshi · 2015 to 2026
$3.5M
NCI NIH HHS R01 CA193343NIH-NCI R01CA193343
6 · The paper itself

Abstract

introductionRadiation therapy for head and neck squamous cell carcinoma is constrained by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for image-guided radiation therapy planning and enhancement in rat head and neck squamous cell carcinoma models.

methodsPEG conjugated theranostic nanoparticles comprising of Au nanorods coated with Gadolinium oxide layers were tested for radiation therapy enhancement in 2D cultures of OSC-19-GFP-luc cells, and orthotopic tongue xenografts in male immunocompromised Salt sensitive or SS rats via both intratumoral and intravenous delivery. The radiation therapy enhancement mechanism was investigated.

resultsTheranostic nanoparticles demonstrated both X-ray/magnetic resonance contrast in a dose-dependent manner. Magnetic resonance images depicted optimal tumor-to-background uptake at 4 h post injection. Theranostic nanoparticle + Radiation treated rats experienced reduced tumor growth compared to controls, and reduction in lung metastasis.

conclusionsTheranostic nanoparticles enable preprocedure radiotherapy planning, as well as enhance radiation treatment efficacy for head and neck tumors.

Indexed as

Head and Neck NeoplasmsMouth NeoplasmsNanoparticlesRadiotherapy, Image-GuidedAnimalsCell Line, TumorHumansMagnetic Resonance ImagingMaleRatsSquamous Cell Carcinoma of Head and NeckX-RaysDNA damagegoldoral squamous cell carcinomaradiosensitizerROS

Identifiers

PMID37469184
PMCPMC10363893
OpenAlexW4384819048

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.