Observational studyGut microbes
Shifting pattern of gut microbiota in pregnant women two decades apart - an observational study.
Observational study in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- The Influences of Oral Probiotics on the Immunometabolic Response During Pregnancy and Lactation: A Systematic Review.Nutrients · 2025Pooled it
- [Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Changes in Healthy Infant Gut Microbiota over the Past Decades.Neonatology · 2026Article
- Allergic diseases are signalling a public health crisis - It is time for a global allergy health plan.The World Allergy Organization journal · 2025Article
- Fecal Short-Chain Fatty Acids Are Associated with Obesity in Gestational Diabetes.Biomedicines · 2025Article
- Resilience to Global Health Challenges Through Nutritional Gut Microbiome Modulation.Nutrients · 2025Review
- Pregnancy exacerbates neutrophil responses in murine lungs and alters gut microbiota composition after cigarette smoke exposure.Frontiers in immunology · 2025Article
- Diets intervene osteoporosis via gut-bone axis.Gut microbesReview
- From biodiversity to nature deficiency in human health and disease.Porto biomedical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPast decades have witnessed a decrease in environmental biodiversity. We hypothesized a similar decrease in indigenous gut microbiota diversity, which may have contributed to the obesity epidemic.
objectiveTo investigate the changes in the composition and function of the gut microbiota in pregnant women over a period of 20 years. STUDY
designAltogether 124 pregnant women (41 overweight and matched 83 normal weight) pregnant in 1997, 2007 or 2017 were included in the study. The gut microbiota composition was assessed from fecal samples obtained at 32 weeks of gestation by 16S rRNA gene sequencing. Fecal short chain fatty acid (SCFA) profiles were measured by gas chromatography mass spectrometry (GC-MS).
resultsDistinct gut microbiota profiles were detected in pregnant women from 1997, 2007 and 2017 (PERMANOVA Bray-Curtis R
conclusionsThe decrease in intestinal microbiota richness and diversity over two decades occurred in parallel with the decline in biodiversity in our natural surroundings. It appears that the gut microbiota of pregnant women has changed over time to a composition typical for overweight individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.