ArticleArthritis research & therapy2023
A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism.
Article in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Breast Cancer and Meningioma Risk: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Association between uric acid-albumin ratio and spontaneous reperfusion in ST-segment elevation myocardial infarction patients.Journal of geriatric cardiology : JGC · 2025Article
- The impact of inflammatory factors on patients with concurrent lung cancer and acute pulmonary embolism.Frontiers in cardiovascular medicine · 2025Article
- Investigating the causal association between serum uric acid levels and gastric cancer risk: a Mendelian randomization study.Scientific reports · 2024Article
- Relationship between serum uric acid levels and pulmonary embolism: an age-based stratified analysis.Thrombosis journal · 2024Article
- Article
- Letter to the editor: "uric acid's influence on venous thromboembolism in East Asia".The Lancet regional health. Western Pacific · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational studies have linked hyperuricemia with venous thromboembolism (VTE). We aimed to investigate whether there are causal relationships between uric acid levels and VTE and its subtypes, including deep venous thrombosis (DVT) of the lower extremities and pulmonary embolism (PE).
methodsWe utilized Mendelian randomization (MR) analysis to estimate the causal association in European individuals. We extracted two sets of polygenic instruments strongly associated (p < 5 × 10
resultsThe genetically instrumented serum uric acid levels had no causal effects on VTE, DVT, and PE. Two sets of polygenic instruments used for exposure, along with three complementary MR methods, also yielded no significant association.
conclusionsOur MR analysis provided no compelling evidence for a causal relationship of serum uric acid with the risk of VTE. This suggests that uric acid-lowering therapies in patients with hyperuricemia may not be effective in reducing the likelihood of developing VTE.
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