Evidence map›Paper›PMID 37468910›Full record

ArticleAIDS research and therapy2023

Cytomegalovirus colitis unmasking human immunodeficiency virus infection as a cause of IgA vasculitis.

Alice Bartoletti, Paolo Delvino, Marco Minetto, Alessandra Milanesi, Emanuele Bozzalla Cassione, Verdiana Serena Quadrelli, Ombretta Luinetti, Sara Monti, Carlomaurizio Montecucco

Open access · goldAbstract readCase Reports
In one paragraph

Article in AIDS research and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alice BartolettiDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy. alice.bartoletti01@universitadipavia.it.
Paolo DelvinoDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.
Marco MinettoDepartment of Molecular Medicine, Unit of Anatomic Pathology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Alessandra MilanesiDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.
Emanuele Bozzalla CassioneDivision of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100, Pavia, Italy.
Verdiana Serena QuadrelliDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.
Ombretta LuinettiDepartment of Molecular Medicine, Unit of Anatomic Pathology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Sara MontiDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.
Carlomaurizio MontecuccoDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.
University of Pavia · ITPoliclinico San Matteo Fondazione · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV) has a protean clinical picture, in rare instances manifesting as systemic autoimmune disorders such as vasculitides. HIV-induced autoimmune diseases often do not respond well to systemic immunosuppressive therapy. Opportunistic infections may occur in patients with either acquired immunodeficiency syndrome (AIDS) or heavy immunosuppressive treatment, and can further complicate the clinical presentation. CASE PRESENTATION: A patient presenting with immunoglobulin A (IgA) vasculitis (IgAV) with treatment-refractory purpuric skin rash and suspect intestinal vasculitis was discovered to have AIDS. HIV was the trigger of IgAV, and cytomegalovirus (CMV) colitis mimicked intestinal vasculitis. Antiretroviral treatment improved both CMV colitis and the control of the autoimmune disease.

conclusionsAn autoimmune disease relapsing despite adequate immunosuppressive treatment and/or the presence of recurrent severe opportunistic infections may be clues to an underlying HIV infection.

Indexed as

Autoimmune DiseasesColitisCytomegalovirus InfectionsHIV InfectionsIgA VasculitisOpportunistic InfectionsVasculitisHIVHumansAIDSCMVHIVIgA vasculitis

Identifiers

PMID37468910
PMCPMC10355054
OpenAlexW4384818947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.