Evidence map›Paper›PMID 37468905›Full record

ArticleAIDS research and therapy2023

Biomedical association analysis between G2/M checkpoint genes and susceptibility to HIV-1 infection and AIDS progression from a northern chinese MSM population.

Jiawei Wu, Lidan Xu, Bangquan Liu, Wenjing Sun, Yuanting Hu, Yi Yang, Keer Guo, Xueyuan Jia, Haiming Sun, Jie Wu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
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Article in AIDS research and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jiawei WuCollege of Basic Medicine, Harbin Medical University-Daqing Campus, Daqing, Heilongjiang Province, 163319, China.
Lidan XuLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Bangquan LiuLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Wenjing SunLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Yuanting HuLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Yi YangLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Keer GuoLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Xueyuan JiaLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Haiming SunLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Jie WuLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Yun HuangLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Wei JiLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Songbin FuLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China.
Yuandong QiaoCollege of Basic Medicine, Harbin Medical University-Daqing Campus, Daqing, Heilongjiang Province, 163319, China. qiaoyuandong@hrbmu.edu.cn.
Xuelong ZhangLaboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang Province, 150081, China. zhangxuelong@hrbmu.edu.cn.
Harbin Medical University · CNHeilongjiang University · CNMinistry of Education of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMSM are at high risk of HIV infection. Previous studies have shown that the cell cycle regulation plays an important role in HIV-1 infection, especially at the G2/M checkpoint. ATR, Chk1, Cdc25C and CDK1 are key genes of G2/M checkpoint. However, the association between SNPs of these genes and susceptibility to HIV-1 infection and AIDS progression remains unknown.

methodsIn this study, 42 tSNPs from the above four G2/M checkpoint genes were genotyped in 529 MSM and 529 control subjects from northern China to analyze this association.

resultsThe results showed that rs34660854 A and rs75368165 A in ATR gene and rs3756766 A in Cdc25C gene could increase the risk of HIV-1 infection (P = 0.049, OR = 1.234, 95% CI 1.001-1.521; P = 0.020, OR = 1.296, 95% CI 1.042-1.611; P = 0.011, OR = 1.392, 95% CI 1.080-1.794, respectively), while Chk1 rs10893405 (P = 0.029, OR = 1.629, 95% CI 1.051-2.523) were significantly associated with AIDS progression. Besides, rs34660854 (P = 0.019, OR = 1.364, 95% CI 1.052-1.769; P = 0.022, OR = 1.337, 95% CI 1.042-1.716, under Codominant model and Dominant model, respectively) and rs75368165 (P = 0.006, OR = 1.445, 95% CI = 1.114-1.899; P = 0.007, OR = 1.418, 95% CI 1.099-1.831, under Codominant model and Dominant model, respectively) in ATR gene, rs12576279 (P = 0.013, OR = 0.343, 95% CI 0.147-0.800; P = 0.048, OR = 0.437, 95% CI 0.192-0.991, under Codominant model and Dominant model, respectively) and rs540436 (P = 0.012, OR = 1.407, 95% CI 1.077-1.836; P = 0.021, OR = 1.359, 95% CI 1.048-1.762, under Codominant model and Dominant model, respectively) in Chk1 gene, rs3756766 (P = 0.013, OR = 1.455, 95% CI 1.083-1.954; P = 0.009, OR = 1.460, 95% CI 1.098-1.940, under Codominant model and Dominant model, respectively) in Cdc25C gene and rs139245206 (P = 0.022, OR = 5.011, 95% CI 1.267-19.816; P = 0.020, OR = 5.067, 95% CI 1.286-19.970, under Codominant model and Recessive model, respectively) in CDK1 gene were significantly associated with HIV-1 infection under different models.

conclusionsWe found that genetic variants of G2/M checkpoint genes had a molecular influence on the occurrence of HIV-1 infection and AIDS progression in a northern Chinese MSM population.

Indexed as

Acquired Immunodeficiency SyndromeCell Cycle CheckpointsHIV InfectionsSexual and Gender MinoritiesAtaxia Telangiectasia Mutated Proteinscdc25 PhosphatasesCDC2 Protein KinaseCheckpoint Kinase 1East Asian PeopleHIV-1Homosexuality, MaleHumansMaleAtaxia Telangiectasia Mutated ProteinsATR protein, humanCDC25C protein, humancdc25 PhosphatasesCDC2 Protein KinaseCDK1 protein, humanCheckpoint Kinase 1CHEK1 protein, humanAIDSG2/M checkpointGene-gene interactionHIV-1MSM populationSNP

Identifiers

PMID37468905
PMCPMC10357704
OpenAlexW4384818694

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