Evidence map›Paper›PMID 37468847›Full record

ArticleBMC pulmonary medicine2023

Clinical outcomes and risk factors of progressive pulmonary fibrosis in primary Sjögren's syndrome-associated interstitial lung disease.

Yu-Hsuan Chen, Tai-Ju Lee, Hsin-Jung Hsieh, Song-Chou Hsieh, Hao-Chien Wang, Yeun-Chung Chang, Chong-Jen Yu, Jung-Yien Chien

Open access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yu-Hsuan ChenDepartment of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
Tai-Ju LeeDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.
Hsin-Jung HsiehDepartment of Internal Medicine, National Taiwan University Hospital Jinshan Branch, New-Taipei, Taiwan.
Song-Chou HsiehDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Hao-Chien WangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yeun-Chung ChangDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Chong-Jen YuDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.
Jung-Yien ChienDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. jychien@ntu.edu.tw.
National Taiwan University Hospital · TWNational Yunlin University of Science and Technology · TW

Funding

Ministry of Science and Technology, Taiwan MOST 107-2314-B-002 -211National Taiwan University Hospital 112-S0108
6 · The paper itself

Abstract

backgroundTo investigate the clinical outcomes and risk factors associated with progressive fibrosing interstitial lung disease (PF-ILD) in patients with primary Sjögren's syndrome-associated interstitial lung disease (pSjS-ILD).

methodsDuring 2015-2021, pSjS patients with ILD were retrospectively identified. Patients were grouped into non-PF-ILD and PF-ILD. Demographics, laboratory data, pulmonary function tests (PFTs), images, survival outcomes were compared between groups.

results153 patients with SjS-ILD were reviewed, of whom 68 having primary SjS-ILD (pSjS-ILD) were classified into non-PF-ILD (n = 34) and PF-ILD groups (n = 34). PF-ILD group had persistently lower albumin levels and a smaller decline in immunoglobulin G (IgG) levels at the 3rd month of follow-up. The multivariate logistic regression analysis revealed that persistently low albumin levels were associated with PF-ILD. At the 12th month, the PF-ILD group experienced a smaller increase in FVC and a greater decline in the diffusion capacity of carbon monoxide (DLCO) than at baseline. The 3-year overall survival rate was 91.2%, and PF-ILD group had significantly poorer 3-year overall survival rate than non-PF-ILD group (82.4% vs. 100%, p = 0.011). Poor survival was also observed among female patients with PF-ILD.

conclusionsAmong patients with pSjS-ILD, the PF-ILD group had poorer 3-year survival outcomes. Persistent lower albumin level might be the risk factor of PF-ILD. Early lung function tests could be helpful for the early detection of PF-ILD.

Indexed as

Lung Diseases, InterstitialPulmonary FibrosisSjogren's SyndromeAlbuminsDisease ProgressionFemaleHumansLungRetrospective StudiesRisk FactorsAlbuminsPrimary Sjögren’s syndrome-associated interstitial lung diseaseProgressive fibrosing

Identifiers

PMID37468847
PMCPMC10357686
OpenAlexW4384820167

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.