Evidence map›Paper›PMID 37468651›Full record

ReviewNature protocols2023

Development of ionic liquid-coated PLGA nanoparticles for applications in intravenous drug delivery.

Christine M Hamadani, Gaya S Dasanayake, Meghan E Gorniak, Mercedes C Pride, Wake Monroe, Claylee M Chism, Rebekah Heintz, Ethan Jarrett, Gagandeep Singh, Sara X Edgecomb and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christine M HamadaniDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.ORCID 0000-0003-4774-6777
Gaya S DasanayakeDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Meghan E GorniakDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Mercedes C PrideDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.ORCID 0000-0003-0785-9013
Wake MonroeDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.ORCID 0000-0002-4265-0576
Claylee M ChismDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Rebekah HeintzDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Ethan JarrettDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.ORCID 0009-0000-0294-4644
Gagandeep SinghDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Sara X EdgecombDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Eden E L TannerDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA. eetanner@olemiss.edu.ORCID 0000-0002-7919-2249

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymeric nanoparticles (NPs) are a promising platform for medical applications in drug delivery. However, their use as drug carriers is limited by biological (e.g., immunological) barriers after intravenous administration. Ionic liquids (ILs), formed from bulky asymmetric cations and anions, have a wide variety of physical internal and external interfacing properties. When assembled on polymeric NPs as biomaterial coatings, these external-interfacing properties can be tuned to extend their circulation half-life when intravenously injected, as well as drive biodistribution to sites of interest for selective organ accumulation. In our work, we are particularly interested in optimizing IL coatings to enable red blood cell hitchhiking in whole blood. In this protocol, we describe the preparation and physicochemical and biological characterization of choline carboxylate IL-coated polymeric NPs. The procedure is divided into five stages: (1) synthesis and characterization of choline-based ILs (1 week); (2) bare poly(lactic-co-glycolic acid) (50:50, acid terminated) Resomer 504H (PLGA) NP assembly, modified from previously established protocols, with dye encapsulation (7 h); (3) modification of the bare particles with IL coating (3 h); (4) physicochemical characterization of both PLGA and IL-PLGA NPs by dynamic light scattering,

Indexed as

Ionic LiquidsNanoparticlesAnimalsDrug CarriersLactic AcidMicePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerTissue DistributionDrug CarriersIonic LiquidsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID37468651

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.