ArticleNature2023
Molecular features driving cellular complexity of human brain evolution.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Gamified Health Promotion in Schools: The Integration of Neuropsychological Aspects and CBT-A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Developmental and cellular vulnerabilities underlie genetic architecture of schizophrenia.Molecular psychiatry · 2026Article
- Characterization of the chromosome 7 locus associated with suicidal behavior.Molecular psychiatry · 2026Article
- Segmentally Duplicated Regulatory Elements Undergo Human-Specific Rewiring.Molecular biology and evolution · 2026Article
- Charting the human-specific properties of gene expression networks in the infant prefrontal cortex.Science advances · 2026Article
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- Comparative analysis of the cellular landscape in mammalian striatum.Nature communications · 2026Article
- Expanding canonical cortical cell type markers in the era of single-cell transcriptomics.Scientific reports · 2026Article
- Prenatal maternal immune activation triggers lasting cell-specific transcriptomic dysregulation in the amygdala of primate offspring.Molecular psychiatry · 2026Article
- Genomic approaches for understanding the evolution of the human brain.Nature neuroscience · 2026Review
- Integration of human and mouse single-cell transcriptomes of the developing cerebellum nominates cells-of-origin for group 3 and 4 medulloblastoma.BMC cancer · 2026Article
- Cross-species prediction reveals chromatin regions with increased accessibility in humans.Science advances · 2026Article
- An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.Genome biology · 2026Article
- Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex.Nature communications · 2026Article
- Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex.Nature neuroscience · 2026Article
- Epigenetic editing: from concept to clinic.Nature reviews. Drug discovery · 2026Review
- Deciphering epileptogenic and activity-dependent gene programs in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Impact of Electroacupuncture on the Expression Profile of the Anterior Cingulate Cortex in a Rat Model of Irritable Bowel Syndrome Based on Transcriptome Sequencing and Bioinformatics Analysis.Journal of pain research · 2026Article
- Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species.Genetics · 2025Article
- Segmentally duplicated regulatory elements undergo human-specific rewiring.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Emre Caglayan *Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5340-8614
Fatma Ayhan *Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.
Yuxiang LiuDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.
Rachael M VollmerDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1794-2278
Emily OhDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.
Chet C SherwoodCenter for the Advanced Study of Human Paleobiology, Department of Anthropology, The George Washington University, Washington, DC, USA.ORCID 0000-0001-6711-449X
Todd M PreussDivision of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Soojin V YiDepartment of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, Santa Barbara, CA, USA. soojinyi@ucsb.edu.ORCID 0000-0003-1497-1871
Genevieve KonopkaDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA. genevieve.konopka@utsouthwestern.edu.ORCID 0000-0002-3363-7302
Southwestern Medical Center · USEmory University · USGeorge Washington University · USUniversity of California, Santa Barbara · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MHuman Specific Brain DNA Methylation and Neuropsychiatric DiseasesR01MH103517 · NIMH · GEORGIA INSTITUTE OF TECHNOLOGY · PI JORDAN, IRVING KING, PREUSS, TODD M · 2015 to 2019
$3.5MFoxp-regulated signaling pathways in brain development - DiversityR01MH126481 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE · 2021 to 2025
$3.4MComparative Epigenomics of Primate BrainsR01HG011641 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KONOPKA, GENEVIEVE, SHERWOOD, CHESTER · 2021 to 2024
$2.4MThe Cellular and Systems Biology of Sleep and Circadian Rhythms Training ProgramT32HL139438 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GREENE, ROBERT W, TAKAHASHI, JOSEPH S · 2018 to 2022
$1.2MA National Chimpanzee Brain ResourceR24NS092988 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI SHERWOOD, CHESTER · 2015 to 2018
$969kAmerican Heart Association-American Stroke Association 915654NHGRI NIH HHS R01 HG011641NHLBI NIH HHS T32 HL139438NIH HHS P51 OD011132NIMH NIH HHS R01 MH103517NIMH NIH HHS R01 MH126481NINDS NIH HHS R24 NS092988
Abstract
Human-specific genomic changes contribute to the unique functionalities of the human brain
Indexed as
Evolution, MolecularGyrus CinguliAnimalsCell NucleusChromatinChromatin Assembly and DisassemblyDatasets as TopicForkhead Transcription FactorsGenome, HumanGenomicsHumansMacaca mulattaNeuronsOligodendrogliaPan troglodytesProto-Oncogene Proteins c-fosChromatinForkhead Transcription FactorsFOS protein, humanFOXP2 protein, humanJUN protein, humanProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junTransposases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.