Evidence map›Paper›PMID 37468626›Full record

ArticleNature2023

RNA polymerase II associates with active genes during DNA replication.

Tyler K Fenstermaker, Svetlana Petruk, Sina K Kovermann, Hugh W Brock, Alexander Mazo

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
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  15. Review
  16. Article
  17. Reduced Levels of Lagging Strand Polymerases Shape Stem Cell Chromatin.bioRxiv : the preprint server for biology · 2024
    Article
  18. Epigenetic control and manipulation of neuronal maturation timing.Current opinion in genetics & development · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tyler K FenstermakerDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-9627-3390
Svetlana PetrukDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Sina K KovermannDepartment of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
Hugh W BrockDepartment of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
Alexander MazoDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. Alexander.Mazo@jefferson.edu.ORCID 0009-0008-7605-6103
Thomas Jefferson University · USUniversity of British Columbia · CA

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Claudio Guillermo Giraudo · 1995 to 2026
$94.8M
TRANSCRIPTIONAL REGULATION BY EPIGENETIC FACTORSR01GM075141 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI MAZO, ALEXANDER M · 2005 to 2021
$4.9M
Training Program in Cellular, Biochemical, and Molecular SciencesT32GM100836 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2012 to 2016
$809k
Recruitment of transcriptional machinery following DNA replicationF31GM128300 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI FENSTERMAKER, TYLER KENNEDY · 2018 to 2021
$102k
NCI NIH HHS P30 CA056036NIGMS NIH HHS F31 GM128300NIGMS NIH HHS R01 GM075141NIGMS NIH HHS T32 GM100836
6 · The paper itself

Abstract

The transcriptional machinery is thought to dissociate from DNA during replication. Certain proteins, termed epigenetic marks, must be transferred from parent to daughter DNA strands in order to maintain the memory of transcriptional states

Indexed as

ChromatinDNADNA ReplicationGenesRNA Polymerase IITranscription, GeneticDNA Polymerase IIEpigenesis, GeneticProliferating Cell Nuclear AntigenRNATranscription Factors, GeneralChromatinDNADNA Polymerase IIProliferating Cell Nuclear AntigenRNARNA Polymerase IITranscription Factors, General

Identifiers

PMID37468626
PMCPMC13343614
OpenAlexW4384819733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.