ArticleNature2023
KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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0cells of the map it votes in
27citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Multifocal ground-glass opacities in lung cancer: a narrative review of genomic evolution, immune ecology, and biology-informed clinical management.Journal of thoracic disease · 2026Review
- ARNTL2 promotes metastatic phenotypes through SERPINE1 transcription in KRAS G12D pancreatic cancer.iScience · 2026Article
- Article
- Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression.bioRxiv : the preprint server for biology · 2026Article
- Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology.bioRxiv : the preprint server for biology · 2026Article
- A Prognostic Signature for Lung Adenocarcinoma in Patients Who Have Never Smoked.Cancer discovery · 2026Article
- Lineage plasticity: a new dilemma in lung cancer treatment.Molecular biology reports · 2026Review
- Targeting lung cancer: synergistic therapeutic strategy of cuproptosis and immunogenic cell death.Frontiers in cell and developmental biology · 2026Review
- Single-nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC).Clinical and translational medicine · 2026Article
- Evolution of Cancer Metastases via Lineage Trans-Differentiation.Research (Washington, D.C.) · 2026Article
- Review
- Review
- Single cell and machine learning identify type II pneumocyte-derived biomarkers HN1/OCIAD2/SFTA2 for non-small cell lung cancer prognosis and immune regulation.European journal of medical research · 2025Article
- A prognostic signature for lung adenocarcinoma in people who have never smoked.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic regulation of cancer stemness.Signal transduction and targeted therapy · 2025Review
- Cellular origins of mucinous ovarian carcinoma.The Journal of pathology · 2025Review
- Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma.Molecular cell · 2025Article
- Single-cell and multi-omics analysis reveals the role of stem cells in prognosis and immunotherapy of lung adenocarcinoma patients.Frontiers in immunology · 2025Article
- Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma.Cell reports · 2024Article
- The mathematical exploration for the mechanism of lung adenocarcinoma formation and progression.Briefings in bioinformatics · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Nicholas H JuulDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jung-Ki YoonDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-4947-1412
Marina C MartinezInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Neha RishiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Yana I KazadaevaDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Maurizio MorriChan-Zuckerberg Biohub, Stanford, CA, USA.
Norma F NeffChan-Zuckerberg Biohub, Stanford, CA, USA.
Winston L TropeDivision of Thoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Joseph B ShragerDivision of Thoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0859-0589
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7511-0798
Tushar J DesaiDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. tdesai@stanford.edu.ORCID 0000-0002-8794-5319
Stanford University · USChan Zuckerberg Initiative (United States) · USCalifornia Institute for Regenerative Medicine · US
Funding
Stanford Training Program in Lung BiologyT32HL129970 · NHLBI · STANFORD UNIVERSITY · PI CORNFIELD, DAVID N., NICOLLS, MARK ROBERT · 2016 to 2025
$3.2MCellular and molecular mechanisms of alveolar repairR01HL167410 · NHLBI · STANFORD UNIVERSITY · PI Tushar Jasubhai DESAI · 2023 to 2026
$2.7MIdentifying niche factors regulating distinct properties of AT2 stem cellsR01HL142549 · NHLBI · STANFORD UNIVERSITY · PI DESAI, TUSHAR JASUBHAI · 2018 to 2021
$2.2MNext-Generation Genomic Imaging TechnologyUH3CA255135 · NCI · STANFORD UNIVERSITY · PI DESAI, TUSHAR JASUBHAI, HARBURY, PEHR A · 2020 to 2021
$795kNext-Generation Genomic Imaging TechnologyUG3HL145623 · NHLBI · STANFORD UNIVERSITY · PI DESAI, TUSHAR JASUBHAI, HARBURY, PEHR A · 2018 to 2019
$760kOneView 4kX4k sCMOS camera for transmission electron microscopy applicationsS10OD028536 · OD · STANFORD UNIVERSITY · PI MULHOLLAND, JONATHAN W · 2020 to 2020
$195kThe role of Nkx2-1 in the distal lungF32HL147417 · NHLBI · STANFORD UNIVERSITY · PI JUUL, NICHOLAS HEDEMANN · 2019 to 2019
$72kNCI NIH HHS UH3 CA255135NHLBI NIH HHS F32 HL147417NHLBI NIH HHS L30 HL143641NHLBI NIH HHS R01 HL142549NHLBI NIH HHS R01 HL167410NHLBI NIH HHS T32 HL129970NHLBI NIH HHS UG3 HL145623NIH HHS S10 OD028536
Abstract
Many cancers originate from stem or progenitor cells hijacked by somatic mutations that drive replication, exemplified by adenomatous transformation of pulmonary alveolar epithelial type II (AT2) cells
Indexed as
Adenocarcinoma of LungCellular ReprogrammingLung NeoplasmsProto-Oncogene Proteins p21(ras)Stem CellsExtracellular Signal-Regulated MAP KinasesHumansExtracellular Signal-Regulated MAP KinasesKRAS protein, humanProto-Oncogene Proteins p21(ras)
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.