ArticleNature methods2023
Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging.
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Article in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
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Who cites it
37 citing papers in PubMed.
- Standardizing Cell Ontology terms for cross-study integration in the female reproductive tract.Science advances · 2026Review
- Understanding and targeting the tumour matrisome.Nature reviews. Clinical oncology · 2026Review
- HuBMAP Data Portal: a resource for multimodal spatial and single-cell data of healthy human tissues.ArXiv · 2026Article
- A Micro-Quantitative and FFPE-Compatible Workflow for Immunohistochemistry-Guided Spatial Proteomic Analysis of Cellular Subpopulations Within the Tumor Microenvironment.Bioengineering (Basel, Switzerland) · 2026Article
- The HuBMAP Framework for Advancing Data FAIRness.bioRxiv : the preprint server for biology · 2026Article
- Cell Type Populations for 3D Anatomical Structures of the Human Reference Atlas.Scientific data · 2026Article
- Spatial proteomics in precision medicine: technologies, bioinformatics, and translational applications.Precision clinical medicine · 2026Review
- SenNet Portal: Build, Optimization and Usage.bioRxiv : the preprint server for biology · 2026Article
- Spatial architecture of development and disease.Nature reviews. Genetics · 2026Review
- Article
- Article
- SPACEc: a streamlined, interactive Python workflow for multiplexed image processing and analysis.Nature communications · 2025Article
- Antibody-Based Multiplex Image Analysis: Standard Analytical Workflows and Artificial Intelligence Tools for Pathologists.Laboratory investigation; a journal of technical methods and pathology · 2025Review
- Article
- Constructing and Using Cell Type Populations of the Human Reference Atlas.bioRxiv : the preprint server for biology · 2025Article
- Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules.Science advances · 2025Article
- Article
- Construction, Deployment, and Usage of the Human Reference Atlas Knowledge Graph.Scientific data · 2025Article
- Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage.Nature methods · 2025Article
- Article
Corrections and comments
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Authors and funding
38 authors.
Ellen M Quardokus *Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.ORCID http://orcid.org/0000-0001-7655-4833
Diane C Saunders *Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-8849-6746
Elizabeth McDonoughGE Research, Niskayuna, NY, USA.ORCID http://orcid.org/0000-0001-7524-8260
John W HickeyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9961-7673
Christopher WerleinInstitute of Pathology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-7694-4257
Christine SurretteGE Research, Niskayuna, NY, USA.
Presha RajbhandariDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Anna Martinez CasalsDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Hua TianDepartment of Chemistry, Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-3598-0219
Lisa LoweryGE Research, Niskayuna, NY, USA.
Elizabeth K NeumannDepartment of Biochemistry, Vanderbilt University, Nashville, TN, USA.
Frida BjörklundScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
Taruna V NeelakantanDepartment of Chemistry, Columbia University, New York, NY, USA.
Josh CroteauDepartment of Business Development, BioLegend Inc., San Diego, CA, USA.ORCID http://orcid.org/0000-0002-8142-0482
Anne E WiblinDepartment of Research and Development, Abcam PLC, Discovery Drive, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-6087-5701
Jeremy FisherDepartment of Research and Development, Cell Signaling Technology, Inc., Danvers, MA, USA.ORCID http://orcid.org/0000-0002-7296-586X
April J LivengoodDepartment of Protein and Cell Analysis, Thermo Fisher Scientific, Carlsbad, CA, USA.
Karen G DowellAkoya Biosciences, Marlborough, MA, USA.
Jonathan C SilversteinDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-9252-6039
Jeffrey M SpragginsDepartment of Biochemistry, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-9198-5498
Gloria S PryhuberDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-9185-3994
Gail DeutschDepartment of Pathology, University of Washington Medical Center, Seattle, WA, USA.
Fiona GintyGE Research, Niskayuna, NY, USA.
Garry P NolanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Simon MelovBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-8554-2834
Danny JonigkInstitute of Pathology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-5251-2281
Michael A CaldwellDepartments of Chemistry, Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.
Ioannis S VlachosSpatial Technologies Unit, Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8849-808X
Werner MullerMiltenyi Biotec B.V. and Co. KG, Bergisch Gladbach, Germany.ORCID http://orcid.org/0000-0002-1297-9725
Nils GehlenborgDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0327-8297
Brent R StockwellDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3532-3868
Emma LundbergDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7034-0850
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0784-7987
Ronald N GermainLaboratory of Immune System Biology, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1495-9143
Jeannie M CamarilloDepartments of Chemistry, Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.
Neil L Kelleher *Departments of Chemistry, Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-8815-3372
Katy Börner *Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.ORCID http://orcid.org/0000-0002-3321-6137
Andrea J RadtkeLaboratory of Immune System Biology, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, NIAID, NIH, Bethesda, MD, USA. andrea.radtke@nih.gov.ORCID http://orcid.org/0000-0003-4379-8967
Funding
Multiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MSenNet Supplement - Consortium BenchmarkingU24CA268108 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Philip D. Blood, JONATHAN C. SILVERSTEIN · 2021 to 2026
$22.1MFlexible Hybrid Cloud Infrastructure for Seamless Integration and Use of Human Biomolecular Data and Reference Maps [1 of 5]OT2OD033759 · OD · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D., SILVERSTEIN, JONATHAN C. · 2022 to 2025
$20.4MTRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7MFunctional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MSenescent cell mapping, identification and validation for human somatic and reproductive tissuesU54AG075932 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Simon Melov, Birgit Schilling · 2021 to 2026
$12.5MBioRepository for INvestigation of Diseases of the Lung (BRINDL) - Phase IIIU01HL148861 · NHLBI · UNIVERSITY OF ROCHESTER · PI GLORIA S PRYHUBER · 2019 to 2026
$9.7MFlexible Hybrid Cloud Infrastructure for Seamless Management of HuBMAP Resources, Including Consortium-Wide and External EngagementOT2OD026675 · OD · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D., SILVERSTEIN, JONATHAN C. · 2018 to 2021
$8.9MVanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human KidneyU54DK134302 · NIDDK · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M, SPRAGGINS, JEFFREY M · 2022 to 2025
$7.1MDefining the functions and translational potential of ferroptosisR35CA209896 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R. · 2016 to 2022
$6.5MNCI NIH HHS R35 CA209896NCI NIH HHS T32 CA196585NCI NIH HHS U24 CA268108NCI NIH HHS UG3 CA256962NCI NIH HHS UG3 CA268105NCI NIH HHS UH3 CA246594NCI NIH HHS UH3 CA246635NCI NIH HHS UH3 CA256962NEI NIH HHS U54 EY032442NHGRI NIH HHS U54 HG010426NHLBI NIH HHS U01 HL148861NHLBI NIH HHS U54 HL145608NHLBI NIH HHS UG3 HL145600NIAMS NIH HHS U54 AR081775NIA NIH HHS R01 AG078803NIA NIH HHS U54 AG075932NIDDK NIH HHS F32 DK128887NIDDK NIH HHS P30 DK020593NIDDK NIH HHS U01 DK120447NIDDK NIH HHS U01 DK133766NIDDK NIH HHS U54 DK134302NIEHS NIH HHS T32 ES007028NIGMS NIH HHS P41 GM108569NIH HHS OT2 OD026671NIH HHS OT2 OD026675NIH HHS OT2 OD033758NIH HHS OT2 OD033759
Abstract
Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Advances in the field now allow high-parameter data collection (>60 targets); however, considerable expertise and capital are needed to construct the antibody panels employed by these methods. Organ mapping antibody panels are community-validated resources that save time and money, increase reproducibility, accelerate discovery and support the construction of a Human Reference Atlas.
Indexed as
AntibodiesCommunity ResourcesDiagnostic ImagingHumansReproducibility of ResultsAntibodies
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