ReviewJournal of perinatology : official journal of the California Perinatal Association2023
A "Gold Standard" Test for Diagnosing and Quantifying Hemolysis in Neonates and Infants.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- End-tidal CO corrected for ambient CO risk adjusted phototherapy threshold for the management of neonatal hyperbilirubinemia: a randomized clinical trial.World journal of pediatrics : WJP · 2025Trial
- Hemolytic hyperbilirubinemia.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- End tidal carbon monoxide and significant hemolysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Bilirubin rate of rise during routine 6-h transcutaneous bilirubin surveillance.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Age-specific ETCOc measured by non-dispersive infrared spectroscopy predicts neonatal phototherapy.Pediatric research · 2026Article
- Kernicterus Continues to Occur in the USA Despite Concerted Preventive Efforts.Case reports in pediatrics · 2026Article
- Hereditary Spherocytosis: Review of Presentation at Birth.Children (Basel, Switzerland) · 2025Article
- End-tidal carbon monoxide for routine monitoring of significant hemolysis in the management of newborn hyperbilirubinemia.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Controversies in our understanding of extreme hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient neonates.Pediatric research · 2025Review
- Exhaled carbon monoxide: variations due to collection method and physiology.Journal of breath research · 2025Article
- Duration of hemolysis among infants with hemolytic disease of the fetus and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Is it time for a precision health approach to the management of newborn hyperbilirubinemia?Journal of perinatology : official journal of the California Perinatal Association · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying "gold standard" diagnostic tests can promote evidence-based neonatology practice. Hemolysis is a pathological shortening of the erythrocyte lifespan, differing from erythrocyte senescence in responsible mechanisms and clinical implications. Diagnosing hemolysis goes beyond a binary (yes vs. no) determination. It is characterized according to magnitude, and as acute vs. chronic, and genetically based vs. not. For neonates with significant hyperbilirubinemia or anemia, detecting hemolysis and quantifying its magnitude provides diagnostic clarity. The 2022 American Academy of Pediatrics (AAP) Clinical Practice Guideline on management of hyperbilirubinemia in the newborn states that hemolysis is a risk factor for developing significant hyperbilirubinemia and neurotoxicity. The guideline recommends identifying hemolysis from any cause, but specific guidance is not provided. A spectrum of laboratory tests has been endorsed as diagnostic methods for hemolysis. Herein we examine these laboratory tests and recommend one as the "gold standard" for diagnosing and quantifying hemolysis in neonates and infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.