ArticleNPJ biofilms and microbiomes2023
Pulcherrimin protects Bacillus subtilis against oxidative stress during biofilm development.
Article in NPJ biofilms and microbiomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 34 citations in OpenAlex.
- Pulcherriminic acid as an antibiofilm effector: expandingJournal of bacteriology · 2026Review
- Orthology-based comparative transcriptomic analysis reveals conserved osmoadaptive responses in Bacillus velezensis and Bacillus paralicheniformis.Archives of microbiology · 2026Article
- Genome shuffling enables quantitative trait locus mapping in Bacillus subtilis.Nature communications · 2026Article
- MeeY and YybP, two proteins regulated by manganese-sensing riboswitches, are required for Bacillus subtilis biofilm formation.NPJ biofilms and microbiomes · 2026Article
- Functional synergistic effects of graphene nanoribbons and surfactant stabilizers on inhibition of growth of biofilm-forming and biofilm non-forming bacteria.Environmental science and pollution research international · 2026Article
- ROS-induced allosteric modulation of NikR promotesVirulence · 2025Article
- Bacillus paralicheniformis strain H12 from saline soil for the management of gray mold in cherry tomatoes.World journal of microbiology & biotechnology · 2025Article
- Complete genome sequence data describing the biosynthetic potential of kanosamine and bacilysin inData in brief · 2025Article
- Identification of widely conserved biosynthetic gene cluster involved in pigment production ofmSystems · 2025Article
- Whole genome sequence analysis of pigmented Bacillus inaquosorum LBA001 revealed biosynthetic gene clusters for a variety of secondary metabolites.Antonie van Leeuwenhoek · 2025Article
- The iron chelator pulcherriminic acid mediates the light response in Bacillus subtilis biofilms.Nature communications · 2025Article
- MitigatingBiofilm · 2025Article
- A novel regulation on the developmental checkpoint protein Sda that controls sporulation and biofilm formation inJournal of bacteriology · 2025Article
- The living medicine inside us:Gut microbes reports · 2025Article
- Pulcherriminic acid relay; aFrontiers in cellular and infection microbiology · 2025Review
- Unraveling the interplay between unicellular parasites and bacterial biofilms: Implications for disease persistence and antibiotic resistance.Virulence · 2024Review
- Development of a Microbioreactor forMicromachines · 2024Article
- Two distinct regulatory systems control pulcherrimin biosynthesis in Bacillus subtilis.PLoS genetics · 2024Article
- Interbacterial Biofilm Competition through a Suite of Secreted Metabolites.ACS chemical biology · 2024Article
- Heterologous pulcherrimin production in Saccharomyces cerevisiae confers inhibitory activity on Botrytis conidiation.FEMS yeast research · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulcherrimin is an iron-binding reddish pigment produced by various bacterial and yeast species. In the soil bacterium Bacillus subtilis, this pigment is synthesized intracellularly as the colorless pulcherriminic acid by using two molecules of tRNA-charged leucine as the substrate; pulcherriminic acid molecules are then secreted and bind to ferric iron extracellularly to form the red-colored pigment pulcherrimin. The biological importance of pulcherrimin is not well understood. A previous study showed that secretion of pulcherrimin caused iron depletion in the surroundings and growth arrest on cells located at the edge of a B. subtilis colony biofilm. In this study, we identified that pulcherrimin is primarily produced under biofilm conditions and provides protection to cells in the biofilm against oxidative stress. We presented molecular evidence on how pulcherrimin lowers the level of reactive oxygen species (ROS) and alleviates oxidative stress and DNA damage caused by ROS accumulation in a mature biofilm. We also performed global transcriptome profiling to identify differentially expressed genes in the pulcherrimin-deficient mutant compared with the wild type, and further characterized the regulation of genes by pulcherrimin that are related to iron homeostasis, DNA damage response (DDR), and oxidative stress response. Based on our findings, we propose pulcherrimin as an important antioxidant that modulates B. subtilis biofilm development.
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