Evidence map›Paper›PMID 37468522›Full record

ArticleNature communications2023

Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B

Romila Mascarenhas, Markus Ruetz, Harsha Gouda, Natalie Heitman, Madeline Yaw, Ruma Banerjee

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Cobalt complexes in biology and medicine: enzymatic functions, pharmacological applications, and health challenges.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. An unusual Co-S bond links BProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Cobalt-Sulfur Coordination Chemistry Drives BJournal of the American Chemical Society · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Romila Mascarenhas *Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Markus Ruetz *Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Harsha GoudaDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Natalie HeitmanDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Madeline YawDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA. rbanerje@umich.edu.ORCID 0000-0001-8332-3275
University of Michigan · US

Funding

User Training & OutreachP30GM138396 · NIGMS · UCHICAGO ARGONNE, LLC · PI JANET L. SMITH · 2020 to 2026
$34.3M
REACTION MECHANISMS OF MAMMALIAN B12-DEPENDENT ENZYMESR01DK045776 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI RUMA V BANERJEE · 1998 to 2026
$9.7M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
NIDDK NIH HHS R01 DK045776NIGMS NIH HHS P30 GM138396NIH HHS S10 OD012289
6 · The paper itself

Abstract

G-proteins function as molecular switches to power cofactor translocation and confer fidelity in metal trafficking. The G-protein, MMAA, together with MMAB, an adenosyltransferase, orchestrate cofactor delivery and repair of B

Indexed as

Amino Acid Metabolism, Inborn ErrorsIntramolecular TransferasesGTP-Binding ProteinsGTP PhosphohydrolasesHumansMethylmalonyl-CoA MutaseMutationGTP-Binding ProteinsGTP PhosphohydrolasesIntramolecular TransferasesMethylmalonyl-CoA Mutase

Identifiers

PMID37468522
PMCPMC10356863
OpenAlexW4384820000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.