Evidence map›Paper›PMID 37468503›Full record

ArticleScientific data2023

Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature.

Avinash Boppana, Sujin Lee, Rajeev Malhotra, Marc Halushka, Katherine S Gustilo, Ellen M Quardokus, Bruce W Herr, Katy Börner, Griffin M Weber

Open access · goldAbstract read
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  14. Functional Tissue Units in the Human Reference Atlas.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Avinash BoppanaRevela, Woburn, Massachusetts, USA.
Sujin LeeDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Rajeev MalhotraDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-0120-4630
Marc HalushkaDepartment of Pathology, Johns Hopkins Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7112-7389
Katherine S GustiloDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, USA.
Ellen M QuardokusDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0001-7655-4833
Bruce W HerrDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0002-6703-7647
Katy BörnerDepartment of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0002-3321-6137
Griffin M WeberDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA. weber@hms.harvard.edu.ORCID 0000-0002-2597-881X
Indiana University Bloomington · USMassachusetts General Hospital · USBeth Israel Deaconess Medical Center · USJohns Hopkins University · US

Funding

The Role of Histone Deacetylase 9 in Vascular CalcificationR01HL142809 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MALHOTRA, RAJEEV · 2018 to 2022
$4.0M
The Human Body Atlas: High-Resolution, Functional Mapping of Voxel, Vector, and Meta DatasetsOT2OD026671 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI BORNER, KATY · 2018 to 2021
$3.5M
The Role of Arylsulfatase in Vascular CalcificationR01HL162928 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PAUL STEFAN DE VRIES, Rajeev Malhotra · 2023 to 2026
$2.6M
NHLBI NIH HHS R01 HL142809NHLBI NIH HHS R01 HL162928NIH HHS OT2 OD026671
6 · The paper itself

Abstract

More than 150 scientists from 17 consortia are collaborating on an international project to build a Human Reference Atlas, which maps all 37 trillion cells in the healthy adult human body. The initial release of this atlas provided hierarchical lists of the anatomical structures, cell types, and biomarkers in 11 organs. Here, we describe the methods we used as part of this initiative to build the first open, computer-readable, and comprehensive database of the adult human blood vasculature, called the Human Reference Atlas-Vasculature Common Coordinate Framework (HRA-VCCF). It includes 993 vessels and their branching connections, 10 cell types, and 10 biomarkers. With this paper we are releasing additional details on vessel types and subtypes, branching sequence, anastomoses, portal systems, microvasculature, functional tissue units, mappings to regions vessels supply or drain, geometric properties of vessels, and links to 3D reference objects. Future versions will add variants and connections to the lymph vasculature; and, it will iteratively expand and improve the database as additional experimental data become available through the participating consortia.

Indexed as

BiomarkersAdultHumansBiomarkers

Identifiers

PMID37468503
PMCPMC10356915
OpenAlexW4384819752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.