ArticleNature communications2023
Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Mechanism-Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Increasing representational capacity in the hippocampal-frontoparietal system underlies hierarchical development of temporal memory.Developmental cognitive neuroscience · 2026Review
- Age-dependent vulnerability to spatial memory interference in APP/PS1 mice.Frontiers in aging neuroscience · 2026Article
- Hippocampal Drift Rate Reflects the Temporal Organization of Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural Representation of Episodic Time.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Hippocampal-guided reconstruction of an event's prior temporal context.bioRxiv : the preprint server for biology · 2025Article
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Maintenance suppression enhances subsequent associative learning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Memory Boost for Recurring Emotional Events Is Driven by Initial Amygdala Response Promoting Stable Neocortical Patterns across Repetitions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Time-dependent consolidation mechanisms of durable memory in spaced learning.Communications biology · 2025Article
- Benefits of spaced learning are predicted by the re-encoding of past experience in ventromedial prefrontal cortex.Cell reports · 2025Article
- Semantic relatedness proactively benefits learning, memory, and interdependence across episodes.eLife · 2024Article
- Differences and similarities between human hippocampal low-frequency oscillations during navigation and mental simulation.bioRxiv : the preprint server for biology · 2024Article
- Time after Time: Preserving Temporal Memories When Experiences Repeat.Journal of cognitive neuroscience · 2024Review
- Principles of intensive human neuroimaging.Trends in neurosciences · 2024Article
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Benefits of spaced learning are predicted by re-encoding of past experience in ventromedial prefrontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Structured memory representations develop at multiple time scales in hippocampal-cortical networks.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Converging, cross-species evidence indicates that memory for time is supported by hippocampal area CA1 and entorhinal cortex. However, limited evidence characterizes how these regions preserve temporal memories over long timescales (e.g., months). At long timescales, memoranda may be encountered in multiple temporal contexts, potentially creating interference. Here, using 7T fMRI, we measured CA1 and entorhinal activity patterns as human participants viewed thousands of natural scene images distributed, and repeated, across many months. We show that memory for an image's original temporal context was predicted by the degree to which CA1/entorhinal activity patterns from the first encounter with an image were re-expressed during re-encounters occurring minutes to months later. Critically, temporal memory signals were dissociable from predictors of recognition confidence, which were carried by distinct medial temporal lobe expressions. These findings suggest that CA1 and entorhinal cortex preserve temporal memories across long timescales by coding for and reinstating temporal context information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.