Evidence map›Paper›PMID 37468475›Full record

ArticleNature communications2023

Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.

James F Mbinta, Alex X Wang, Binh P Nguyen, Janine Paynter, Prosper Mandela A Awuni, Russell Pine, Andrew A Sporle, Steve Bowe, Colin R Simpson

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

James F MbintaSchool of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington, New Zealand. james.mbinta@vuw.ac.nz.ORCID 0000-0003-1985-6303
Alex X WangSchool of Mathematics and Statistics, Wellington Faculty of Engineering, Victoria University of Wellington, Wellington, New Zealand.
Binh P NguyenSchool of Mathematics and Statistics, Wellington Faculty of Engineering, Victoria University of Wellington, Wellington, New Zealand.ORCID 0000-0001-6203-6664
Janine PaynterDepartment of General Practice & Primary Healthcare, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-8833-4501
Prosper Mandela A AwuniSchool of Kinesiology and Health Sciences, Laurentian University, Sudbury, Canada.ORCID 0000-0001-8603-919X
Russell PineSchool of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington, New Zealand.ORCID 0000-0002-0224-3757
Andrew A SporleiNZight Analytics Ltd., Department of Statistics, Faculty of Science, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-1620-473X
Steve BoweSchool of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington, New Zealand.ORCID 0000-0003-3813-842X
Colin R SimpsonSchool of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington, New Zealand. colin.simpson@vuw.ac.nz.ORCID 0000-0002-5194-8083
Victoria University of Wellington · NZUniversity of Auckland · NZLaurentian University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Aotearoa New Zealand, zoster vaccine live is used for the prevention of zoster and associated complications in adults. This study assessed the risk of pre-specified serious adverse events following zoster vaccine live immunisation among adults in routine clinical practice. We conducted a self-controlled case series study using routinely collected national data. We compared the incidence of serious adverse events during the at-risk period with the control period. Rate ratios were estimated using Conditional Poisson regression models. Falsification outcomes analyses were used to evaluate biases in our study population. From April 2018 to July 2021, 278,375 received the vaccine. The rate ratio of serious adverse events following immunisation was 0·43 (95% confidence interval [CI]: 0·37-0·50). There was no significant increase in the risk of cerebrovascular accidents, acute myocardial infarction, acute pericarditis, acute myocarditis, and Ramsay-Hunt Syndrome. The herpes zoster vaccine is safe in adults in Aotearoa New Zealand.

Indexed as

Herpes ZosterHerpes Zoster VaccineStrokeAdultHumansNew ZealandResearch DesignHerpes Zoster Vaccine

Identifiers

PMID37468475
PMCPMC10356758
OpenAlexW4384820041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.