ArticleNature communications2023
Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- An OpIE2-DsRed marker disrupts female blood-feeding and shortens lifespan in the malaria vector Anopheles gambiae.Genetics · 2026Article
- Genomic signatures of selection inbioRxiv : the preprint server for biology · 2026Article
- Using a female-specific isoform ofiScience · 2025Article
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- The GABAiScience · 2025Article
- A mosquito-inspired theoretical framework for acoustic signal detection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Diversity and complexity of auditory representation in the hearing systems ofScience advances · 2025Article
- Hematophagy Generates a Convergent Genomic Signature in Mosquitoes and Sandflies.Genome biology and evolution · 2025Article
- Molecular correlates of swarming behaviour inBiology letters · 2024Article
- Mosquitoes integrate visual and acoustic cues to mediate conspecific interactions in swarms.Current biology : CB · 2024Article
- Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter.PLoS genetics · 2024Article
- Monoaminergic Systems in Flight-Induced Potentiation of Phonotactic Behavior in Female CricketsInsects · 2024Article
- The octopamine receptor OAα1 influences oogenesis and reproductive performance in Rhodnius prolixus.PloS one · 2023Article
- The auditory efferent system in mosquitoes.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 5 countries.
Funding
Abstract
Malaria mosquitoes acoustically detect their mating partners within large swarms that form transiently at dusk. Indeed, male malaria mosquitoes preferably respond to female flight tones during swarm time. This phenomenon implies a sophisticated context- and time-dependent modulation of mosquito audition, the mechanisms of which are largely unknown. Using transcriptomics, we identify a complex network of candidate neuromodulators regulating mosquito hearing in the species Anopheles gambiae. Among them, octopamine stands out as an auditory modulator during swarm time. In-depth analysis of octopamine auditory function shows that it affects the mosquito ear on multiple levels: it modulates the tuning and stiffness of the flagellar sound receiver and controls the erection of antennal fibrillae. We show that two α- and β-adrenergic-like octopamine receptors drive octopamine's auditory roles and demonstrate that the octopaminergic auditory control system can be targeted by insecticides. Our findings highlight octopamine as key for mosquito hearing and mating partner detection and as a potential novel target for mosquito control.
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