Evidence map›Paper›PMID 37467718›Full record

ArticleCell reports. Medicine2023

A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence.

Francois Xavier Rwandamuriye, Cameron W Evans, Ben Wylie, Marck Norret, Breana Vitali, Diwei Ho, Dat Nguyen, Ellise A Roper, Tao Wang, Matt S Hepburn and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  11. Immunotherapies for locally aggressive cancers.Advanced drug delivery reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Francois Xavier RwandamuriyeTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Cameron W EvansSchool of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia.
Ben WylieTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Marck NorretSchool of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia.
Breana VitaliTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Diwei HoSchool of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia.
Dat NguyenTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Ellise A RoperTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Tao WangTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Matt S HepburnBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, Australia; Centre for Medical Research, The University of Western Australia, Crawley, WA, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley, WA, Australia.
Rowan W SandersonBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, Australia; Centre for Medical Research, The University of Western Australia, Crawley, WA, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley, WA, Australia.
Maren PfirrmannTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia; Department of Medical BioSciences, Radboud University Medical Centre, Nijmegen, the Netherlands.
Vanessa S FearTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Catherine A ForbesTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Ken WyattPerth Veterinary Specialists, Osborne Park, WA, Australia; Murdoch Veterinary School, Murdoch University, Murdoch, WA, Australia.
Anne L RyanTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia; Department of Oncology, Hematology and Tissue and Cellular Therapies, Perth Children's Hospital, Perth, WA, Australia.
Terrance G JohnsTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Marianne B PhillipsTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia; Department of Oncology, Hematology and Tissue and Cellular Therapies, Perth Children's Hospital, Perth, WA, Australia.
Rupert HodderDepartment of Surgery, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Connull LeslieDepartment of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia.
Brendan F KennedyBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, Australia; Centre for Medical Research, The University of Western Australia, Crawley, WA, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley, WA, Australia.
Rachael M ZemekTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia.
Killugudi Swaminathan IyerSchool of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia. Electronic address: swaminatha.iyer@uwa.edu.au.
Willem Joost LesterhuisTelethon Kids Institute, The University of Western Australia, Nedlands, WA, Australia. Electronic address: willem.lesterhuis@uwa.edu.au.
The Kids Research Institute Australia · AUThe University of Western Australia · AUMurdoch University · AUQueen Elizabeth II Medical Centre · AURadboud University Nijmegen · NLSir Charles Gairdner Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects. Here, we develop a surgically optimized biodegradable hyaluronic acid-based hydrogel for sustained intraoperative delivery of Toll-like receptor 3 agonist poly(I:C) and demonstrate that it significantly reduces tumor recurrence after surgery in multiple mouse models. Mechanistically, poly(I:C) induces a transient interferon alpha (IFNα) response, reshaping the tumor/wound microenvironment by attracting inflammatory monocytes and depleting regulatory T cells. We demonstrate that a pre-existing IFN signature predicts response to the poly(I:C) hydrogel, which sensitizes tumors to immune checkpoint therapy. The safety, immunogenicity, and surgical feasibility are confirmed in a veterinary trial in canine soft tissue tumors. The surgically optimized poly(I:C)-loaded hydrogel provides a safe and effective approach to prevent cancer recurrence.

Indexed as

HydrogelsNeoplasm Recurrence, LocalAnimalsDisease Models, AnimalDogsImmunotherapyMiceTumor MicroenvironmentHydrogelscancerdrug deliveryhydrogelimmunotherapyPD-1poly(I:C)surgical oncologyToll-like receptortumorwound healing

Identifiers

PMID37467718
PMCPMC10394259
OpenAlexW4384701001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.