Evidence map›Paper›PMID 37467372›Full record

ArticleACS synthetic biology2023

Deep Neural Networks for Predicting Single-Cell Responses and Probability Landscapes.

Heidi E Klumpe, Jean-Baptiste Lugagne, Ahmad S Khalil, Mary J Dunlop

Abstract read
In one paragraph

Article in ACS synthetic biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Heidi E KlumpeBiomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Jean-Baptiste LugagneBiomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Ahmad S KhalilBiomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-8214-0546
Mary J DunlopBiomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-9261-8216

Funding

Synthetic toolkit for precision gene expression control and signal processing in mammalian cellsR01EB029483 · NIBIB · HARVARD UNIVERSITY · PI Ahmad Samir Khalil · 2020 to 2026
$5.0M
Feedback and Noise in a Multiple Antibiotic Resistance CircuitR01AI102922 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Mary J. Dunlop · 2014 to 2026
$4.7M
NIAID NIH HHS R01 AI102922NIBIB NIH HHS R01 EB029483
6 · The paper itself

Abstract

Engineering biology relies on the accurate prediction of cell responses. However, making these predictions is challenging for a variety of reasons, including the stochasticity of biochemical reactions, variability between cells, and incomplete information about underlying biological processes. Machine learning methods, which can model diverse input-output relationships without requiring

Indexed as

Machine LearningNeural Networks, ComputerGene Regulatory NetworksProbabilitySynthetic Biologybistabilitydeep learning modelsgene expression dynamicsnoisesingle celltime-series prediction

Identifiers

PMID37467372
PMCPMC11976981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.