Evidence map›Paper›PMID 37466856›Full record

ArticleBulletin of experimental biology and medicine2023

Protective Effect of a New Monophenolic Antioxidant TS-13 in a Mouse Model of Parkinson's Disease.

E B Menshchikova, M V Khrapova, P M Kozhin, A V Chechushkov, A E Serykh, L P Romakh, N V Kandalintseva

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

E B MenshchikovaFederal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. lemen@centercem.ru.
M V KhrapovaFederal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
P M KozhinFederal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
A V ChechushkovFederal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
A E SerykhFederal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
L P RomakhFederal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
N V KandalintsevaNovosibirsk State Pedagogical University, Novosibirsk, Russia.
Federal Research Center of Fundamental and Translational Medicine · RURussian Academy of Sciences · RUNovosibirsk State Pedagogical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of means of the prevention and treatment of age-related neurodegenerative diseases, as well as geroprotectors, among other things, is based on the inflammatory and free radical theories of aging. In this context, we studied the effect of sodium monophenol 3-(3'-tert-butyl-4'-hydroxyphenyl)propyl thiosulfonate (TS-13) on the behavioral and locomotor activity of C57BL/6 mice in modeling Parkinson's disease by MPTP neurotoxin injection. TS-13 administration significantly improved orientation and exploratory activity and emotional response of the animals in the open field test, but did not affect the increase in anxiety caused by MPTP injection. Long-term (6 months) TS-13 administration did not suppress spontaneous motor activity in BALB/c mice and slightly increased their exploratory activity.

Indexed as

Neurodegenerative DiseasesParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAntioxidantsDisease Models, AnimalMiceMice, Inbred C57BL1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAntioxidantsagingantioxidantsKeap1/Nrf2/ARE systemParkinson’s diseasereactive oxygen species

Identifiers

PMID37466856
OpenAlexW4384664858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.