Evidence map›Paper›PMID 37466853›Full record

ArticleBulletin of experimental biology and medicine2023

The Role of Methylation of a Group of microRNA Genes in the Pathogenesis of Metastatic Renal Cell Carcinoma.

N A Ivanova, A M Burdennyi, S S Lukina, E A Filippova, I V Pronina, A V Karpukhin, V B Matveev, T P Kazubskaya, V I Loginov, E A Braga and 1 more

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Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

N A IvanovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
A M BurdennyiResearch Institute of General Pathology and Pathophysiology, Moscow, Russia. burdennyy@gmail.com.
S S LukinaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
E A FilippovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
I V ProninaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
A V KarpukhinN. P. Bochkov Research Center for Medical Genetics, Moscow, Russia.
V B MatveevN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
T P KazubskayaN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
V I LoginovResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
E A BragaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
N E KushlinskiiN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUMinistry of Health of the Russian Federation · RUResearch Centre for Medical Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of methylation of 9 miRNA genes in the pathogenesis of metastatic clear cell renal cell carcinoma was determined by quantitative methylation-specific PCR (MS-PCR). For 5 genes (MIR125B-1, MIR137, MIR193A, MIR34B/C, and MIR375), a significant correlation of high methylation level with late (III-IV) stages, large size (T3+T4) of the tumor, and metastasis to lymph nodes and/or distant organs was revealed. For another group of genes (MIR125B-1, MIR1258, MIR193A, MIR34B/C, and MIR375), a statistically significant correlation of high methylation level with loss of differentiation in the tumor (G3-G4) was found, and the opposite pattern was found for MIR203A. A total of 7 microRNA genes (MIR125B-1, MIR1258, MIR137, MIR193A, MIR203A, MIR34B/C, and MIR375) were identified, the methylation of which is associated with the progression of metastatic clear cell renal cell carcinoma. For 6 of them (except MIR34B/C) these data were obtained for the first time. Thus, new factors of the development and progression of clear cell renal cell carcinoma were identified as potential biomarkers for the early diagnosis and prognosis of metastatic clear cell renal cell carcinoma.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsMicroRNAsBiomarkers, TumorDNA MethylationGene Expression Regulation, NeoplasticHumansBiomarkers, TumorMicroRNAsMIRN1258 microRNA, humanMIRN137 microRNA, humanbiomarkersmetastasismethylationmicroRNA genesrenal cell carcinoma

Identifiers

PMID37466853
OpenAlexW4384664168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.