Evidence map›Paper›PMID 37466773›Full record

ArticleAdvances in experimental medicine and biology2023

Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs.

Pablo Torres-Vergara, Robin Rivera, Carlos Escudero, Jeffrey Penny

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Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pablo Torres-VergaraDepartamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile. pabltorr@udec.cl.
Robin RiveraDepartamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
Carlos EscuderoGrupo de Investigación Vascular (GRIVAS), Universidad del Bio-Bio, Chillán, Chile.
Jeffrey PennyDivision of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Health and Medicine, The University of Manchester, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence from preclinical and clinical studies demonstrate that pregnancy is a physiological state capable of modifying drug disposition. Factors including increased hepatic metabolism and renal excretion are responsible for impacting disposition, and the role of membrane transporters expressed in biological barriers, including the placental- and blood-brain barriers, has received considerable attention. In this regard, the brain disposition of drugs in the mother and fetus has been the subject of studies attempting to characterize the mechanisms by which pregnancy could alter the expression of ATP-binding cassette (ABC) and solute carrier (SLC) transporters. This chapter will summarize findings of the influence of pregnancy on the maternal and fetal expression of ABC and SLC transporters in the brain and the consequences of such changes on the disposition of therapeutic drugs.

Indexed as

ATP-Binding Cassette TransportersPlacentaAdenosine TriphosphateBlood-Brain BarrierFemaleFetusHumansMembrane Transport ProteinsPregnancyAdenosine TriphosphateATP-Binding Cassette TransportersMembrane Transport ProteinsATP-binding cassetteBrainBrain endothelial cellChoroid plexusDrug dispositionFetusMotherPregnancySolute carrierTransporter

Identifiers

PMID37466773

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.