Evidence map›Paper›PMID 37466741›Full record

ArticleAAPS PharmSciTech2023

Preclinical Investigation of Transdermal Route for Enhanced Bio-performance of Duloxetine HCl.

Rajiv Kumar, V R Sinha, Lalita Dahiya, Amita Sarwal

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajiv KumarUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India. rajivuips1981@gmail.com.ORCID http://orcid.org/0000-0002-8087-2401
V R SinhaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.
Lalita DahiyaInstitute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India.
Amita SarwalUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India. sarwalamita@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to develop and optimise drug-in-adhesive (DIA) transdermal patch of duloxetine HCl for enhanced drug delivery. DIA patch so developed reduced the dose and dosing frequency by enhancing bio-performance of the drug. A transdermal DIA patch having Duro-Tak 87-2287 as DIA polymer and Transcutol P as permeation enhancer loaded with 40% drug previously complexed with MeβCD duly characterised (FTIR, DSC, and SEM) was developed for in vivo study. Pharmacokinetic parameters of developed formulation were assessed and compared with oral route of administration. Among various permeation enhancers (PEs), Transcutol P exhibited most enhanced permeation (ER ≈ 1.99) in terms of flux and Q

Indexed as

AdhesivesSkin AbsorptionAdministration, CutaneousAnimalsDuloxetine HydrochlorideEthylene GlycolsRatsRats, WistarSkinTransdermal PatchAdhesivescarbitolDuloxetine HydrochlorideEthylene Glycolspermeation enhancerpharmacokineticspoorly water-soluble drugspray dryingtransdermal

Identifiers

PMID37466741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.