Evidence map›Paper›PMID 37466108›Full record

ArticleHistology and histopathology2023

Expression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report.

Claudia Lombardo, Giuseppe Broggi, Ermanno Vitale, Caterina Ledda, Carla Loreto, Serena Matera, Maria Hagnas, Rosario Caltabiano, Veronica Filetti

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Article in Histology and histopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Claudia LombardoDepartment of Biomedical and Biotechnology Sciences, Section of Human Anatomy, Histology and Sciences of Movement, University of Catania, Catania, Italy.
Giuseppe BroggiDepartment of Medical and Surgical Sciences and Advanced Technologies, "G.F. Ingrassia", Anatomic Pathology, University of Catania, Catania, Italy.
Ermanno VitaleDepartment of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy. ermannovitale@gmail.com.
Caterina LeddaDepartment of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy.
Carla LoretoDepartment of Biomedical and Biotechnology Sciences, Section of Human Anatomy, Histology and Sciences of Movement, University of Catania, Catania, Italy.
Serena MateraDepartment of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy.
Maria HagnasRovaniemi Health Center, Rovaniemi, Finland.
Rosario Caltabiano *Department of Medical and Surgical Sciences and Advanced Technologies, "G.F. Ingrassia", Anatomic Pathology, University of Catania, Catania, Italy.
Veronica Filetti *Department of Biomedical and Biotechnology Sciences, Section of Human Anatomy, Histology and Sciences of Movement, University of Catania, Catania, Italy.
University of Catania · ITUniversity of Oulu · FI

Funding

Interdepartment "PIA.CE.RI" Research Plan of University of Catania 2020/2022
6 · The paper itself

Abstract

backgroundMesothelioma is strongly associated with exposure to asbestos fibers, however, recent studies have also linked exposure to "naturally occurring asbestos" fibers with this disease. Fluoro-edenite, a silicate mineral found in the southeast of Biancavilla (Sicily, Italy), has been identified as a potential risk factor for mesothelioma. Unfortunately, this cancer often has a poor prognosis, and current diagnostic and prognostic biomarkers are inadequate. Histological subtype, gender, and age at diagnosis are the most significant parameters for mesothelioma. Stathmin, a cytosolic protein that regulates cell growth and migration and is overexpressed in many human malignancies, has not yet been linked to mesothelioma survival or clinical-pathological variables.

aimThe aim of this study was to investigate the immunohistochemical expression of stathmin in ten mesothelioma tissue samples with available clinical and follow-up data. MATERIAL AND

methodsParaffin-embedded tissue samples from ten mesothelioma patients were processed for immunohistochemical analyses to evaluate stathmin expression.

resultsOur findings suggest that stathmin overexpression is associated with shorter overall survival in patients with mesothelioma. Furthermore, stathmin expression was significantly correlated with the survival time of mesothelioma patients.

conclusionOur results suggest that stathmin expression may serve as a potential prognostic biomarker for mesothelioma. This biomarker could be used to promptly identify patients with poor prognosis and to guide clinicians in the selection of treatment options.

Indexed as

AsbestosLung NeoplasmsMesotheliomaMesothelioma, MalignantBiomarkersHumansSicilyStathminAsbestosBiomarkersStathminSTMN1 protein, human

Identifiers

PMID37466108
OpenAlexW4384665114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.