Evidence map›Paper›PMID 37465999›Full record

Observational studyStroke2023

White Matter Integrity and Chronic Poststroke Upper Limb Function: An ENIGMA Stroke Recovery Analysis.

Martin Domin, Brenton Hordacre, Pavel Hok, Lara A Boyd, Adriana B Conforto, Justin W Andrushko, Michael R Borich, Richard C Craddock, Miranda R Donnelly, Adrienne N Dula and 11 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Collaborative AI for precision neurorehabilitation: a roadmap.Journal of neuroengineering and rehabilitation · 2025
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Martin DominFunctional Imaging Unit, Diagnostic and Neuroradiology, University Hospital Greifswald, Germany (M.D., P.H., M.L.).ORCID 0000-0002-8620-966X
Brenton HordacreIIMPACT in Health, University of South Australia, Adelaide (B.H.).ORCID 0000-0002-7129-6684
Pavel HokFunctional Imaging Unit, Diagnostic and Neuroradiology, University Hospital Greifswald, Germany (M.D., P.H., M.L.).ORCID 0000-0003-1010-384X
Lara A BoydDepartment of Physical Therapy, University of British Columbia, Vancouver, Canada (L.A.B., J.W.A.).ORCID 0000-0002-2828-4549
Adriana B ConfortoHospital das Clínicas, São Paulo University, Brazil (A.B.C.).ORCID 0000-0001-7869-3490
Justin W AndrushkoDepartment of Physical Therapy, University of British Columbia, Vancouver, Canada (L.A.B., J.W.A.).ORCID 0000-0003-2258-1689
Michael R BorichDepartment of Rehabilitation Medicine, Emory School of Medicine, Atlanta, GA (M.R.B.).ORCID 0000-0001-9897-9867
Richard C CraddockDepartment of Diagnostic Medicine (R.C.C.), The University of Texas at Austin.ORCID 0000-0002-4950-1303
Miranda R DonnellyChan Division of Occupational Science and Occupational Therapy (M.R.D., B.P.L., S.-L.L.), University of Southern California, Los Angeles.ORCID 0000-0002-1983-3008
Adrienne N DulaDepartment of Neurology, Dell Medical School at The University of Texas Austin (A.N.D., S.J.W.).ORCID 0000-0002-4809-6115
Steven J WarachDepartment of Neurology, Dell Medical School at The University of Texas Austin (A.N.D., S.J.W.).ORCID 0000-0003-3125-7979
Steven A KautzDepartment of Health Sciences & Research (S.A.K., N.J.S., S.S.), Medical University of South Carolina, Charleston.ORCID 0000-0003-3151-8235
Bethany P LoChan Division of Occupational Science and Occupational Therapy (M.R.D., B.P.L., S.-L.L.), University of Southern California, Los Angeles.ORCID 0000-0001-7626-9020
Christian SchranzDepartment of Rehabilitation Sciences (C.S., N.J.S.), Medical University of South Carolina, Charleston.ORCID 0000-0003-1102-7180
Na Jin SeoDepartment of Health Sciences & Research (S.A.K., N.J.S., S.S.), Medical University of South Carolina, Charleston.ORCID 0000-0001-6446-5905
Shraddha SrivastavaDepartment of Health Sciences & Research (S.A.K., N.J.S., S.S.), Medical University of South Carolina, Charleston.ORCID 0000-0002-5651-919X
Kristin A WongDepartment of Physical Medicine & Rehabilitation (K.A.W.), The University of Texas at Austin.ORCID 0009-0004-0163-0466
Artemis Zavaliangos-PetropuluBrain Mapping Center, Department of Neurology, Geffen School of Medicine, University of California, Los Angeles (A.Z.-P.).ORCID 0000-0003-1953-8663
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine (P.M.T.), University of Southern California, Los Angeles.
Sook-Lei LiewChan Division of Occupational Science and Occupational Therapy (M.R.D., B.P.L., S.-L.L.), University of Southern California, Los Angeles.ORCID 0000-0001-5935-4215
Martin LotzeFunctional Imaging Unit, Diagnostic and Neuroradiology, University Hospital Greifswald, Germany (M.D., P.H., M.L.).ORCID 0000-0003-4519-4956

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Supplement to Effects of global brain health on sensorimotor recovery after strokeR01NS115845 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIEW, SOOK-LEI · 2020 to 2024
$3.2M
Altering Activation Patterns in the Distal Upper Extremity After StrokeR01HD075813 · NICHD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI ROTH, ELLIOT J. · 2014 to 2019
$1.9M
NICHD NIH HHS R01 HD075813NIGMS NIH HHS P20 GM109040NINDS NIH HHS R01 NS115845RRD VA IK6 RX003075
6 · The paper itself

Abstract

backgroundIntegrity of the corticospinal tract (CST) is an important biomarker for upper limb motor function following stroke. However, when structurally compromised, other tracts may become relevant for compensation or recovery of function.

methodsWe used the ENIGMA Stroke Recovery data set, a multicenter, retrospective, and cross-sectional collection of patients with upper limb impairment during the chronic phase of stroke to test the relevance of tracts in individuals with less and more severe (laterality index of CST fractional anisotropy ≥0.25) CST damage in an observational study design. White matter integrity was quantified using fractional anisotropy for the CST, the superior longitudinal fascicle, and the callosal fibers interconnecting the primary motor cortices between hemispheres. Optic radiations served as a control tract as they have no a priori relevance for the motor system. Pearson correlation was used for testing correlation with upper limb motor function (Fugl-Meyer upper extremity).

resultsFrom 1235 available data sets, 166 were selected (by imaging, Fugl-Meyer upper extremity, covariates, stroke location, and stage) for analyses. Only individuals with severe CST damage showed a positive association of fractional anisotropy in both callosal fibers interconnecting the primary motor cortices (

conclusionsOur data support the notion that individuals with more severe damage of the CST depend on residual pathways for achieving better upper limb outcome than those with less affected CST.

Indexed as

StrokeWhite MatterCross-Sectional StudiesHumansPyramidal TractsRecovery of FunctionRetrospective StudiesUpper Extremitycorticospinal tractdiffusion tensor imagingneuroimagingstrokeupper extremitywhite matter

Identifiers

PMID37465999
PMCPMC10529837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.