ArticleAnnals of surgery2023
Novel Benchmark Values for Open Major Anatomic Liver Resection in Non-cirrhotic Patients: A Multicentric Study of 44 International Expert Centers.
Abstract readMulticenter Study
In one paragraph
Article in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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14 citing papers in PubMed, 12 citations in OpenAlex.
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Authors and funding
96 authors at 20 institutions in 18 countries.
Richard X Sousa Da SilvaSwiss HPB and Transplant Center Zurich, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Eva BreuerSwiss HPB and Transplant Center Zurich, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Sadhana ShankarDepartment of Hepatobiliary and Pancreatic Surgery, King's College Hospital, London, UK.
Shoji KawakatsuDivision of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Wacław HołówkoDepartment of General, Transplant and Liver Surgery, Medical University Warsaw, Warsaw, Poland.
João Santos CoelhoHepato-Biliary-Pancreatic and Transplantation Centre, Curry Cabral Hospital, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.
Heithem JeddouDepartment of Hepatobiliary and Digestive Surgery, Rennes University Hospital, Rennes, France.
Teiichi SugiuraDivision of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Mohammed GhallabPaul Brousse Hospital, AP-HP, University Paris-Saclay, Villejuif, France.
Doris Da SilvaDepartment of HPB Surgery and Liver Transplantation, AP-HP Beaujon Hospital, University of Paris Cité, Clichy, France.
Genki WatanabeHepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Florin BoteaDepartment of Surgery and Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
Nozomu SakaiDepartment of General Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan.
Pietro AddeoHepato-Pancreato-Biliary Surgery and Liver Transplantation, University Hospital, Strasbourg University, Strasbourg, France.
Stylianos TzedakisDepartment of Hepatobiliary, Digestive and Endocrine Surgery, Cochin Hospital, Paris Cité University, Paris, France.
Fabian BartschDepartment of General, Visceral and Transplantation Surgery, University Hospital of Mainz, Mainz, Germany.
Kaja BalcerDepartment of Digestive Surgery and Transplantation, CHU Lille, University Lille, Lille, France.
Chetana LimDepartment of Digestive, Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP Pitié-Salpêtrière, Sorbonne Université, Centre de Recherche de Saint-Antoine, Paris, France.
Fabien WereyDepartment of Oncology and Digestive Surgery, CHU Amiens-Picardie, Amiens, France.
Victor Lopez-LopezClinic and University Virgen de la Arrixaca Hospital, IMIB, Murcia, Spain.
Luciana Peralta MonteroHepato-Pancreato-Biliary Surgery Section and Liver Transplant Unit, General Surgery Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Rodrigo Sanchez ClariaHepato-Pancreato-Biliary Surgery Section and Liver Transplant Unit, General Surgery Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Jennifer LeitingDivision of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN.
Neeta VachharajaniDepartment of Surgery, Section of Abdominal Organ Transplant, Washington University School of Medicine, St Louis, MO.
Eve HoppingHepatobiliary Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide & Hepatobiliary Unit, Department of Surgery, Flinders Medical Centre, Adelaide, Australia.
Orlando J M TorresDepartment of Gastrointestinal Surgery, Hepatopancreatobiliary Unit, Presidente Dutra Hospital, São Luiz, Brazil.
Satoshi HiranoDepartment of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Daan AndelDepartment of Surgical Oncology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands.
Jeroen HagendoornDepartment of Surgical Oncology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands.
Alicja PsicaDepartment of Transplantation and Hepatobiliary Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Matteo RavaioliHepato-biliary surgery and Transplant Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Keun Soon AhnDivision of Hepatobiliary-Pancreatic Surgery, Department of Surgery, School of Medicine, Keimyung University, Dongsan Hospital, Daegu, Republic of Korea.
Tim ReeseDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Asklepios Hospital Barmbek, Semmelweis University of Medicine, Asklepios Campus Hamburg, Hamburg, Germany.
Leonardo A MontesGeneral Surgery Department Liver, Pancreas and Intestinal Transplant Unit, Favaloro Foundation University Hospital, Buenos Aires, Argentina.
Ganesh GunasekaranDepartment of Surgery, Division of HPB Service, Icahn School of Medicine at Mount Sinai, New York, NY.
Cándido AlcázarDepartment of Surgery, HPB and Transplant Unit, General Universitary Hospital Alicante and Health and Biomedical Research Institute of Alicante, Alicante, Spain.
Jin Hong LimDepartment of Surgery, Division of HBP Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Muhammad HaroonDepartment of HPB and Liver Transplant, Bahria International Hospital Orchard, Lahore, Pakistan.
Qian LuHepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Antonio CastaldiDepartment of Digestive Surgery and Liver Transplant Unit, University Côte d'Azur, CHU de Nice, Nice, France.
Tatsuya OrimoDepartment of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Beat MoeckliDivision of Abdominal and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland.
Teresa AbadíaHPB Surgical Division, Miguel Servet University Hospital, Zaragoza, Spain.
Luis RuffoloDepartment of HPB and Transplant Surgery, University of Rochester, Rochester, NY.
Josefina Dib HasanTransplant Unit, Hospital Aleman de Buenos Aires, Buenos Aires, Argentina.
Francesca RattiDivision of Hepatobiliary Surgery, IRCCS San Raffaele Hospital, Vita-Salute University, Milan, Italy.
Emmanuele F KauffmannDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
Roeland F de WildeDepartment of Surgery, Division of HPB and Transplant Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Wojciech G PolakDepartment of Surgery, Division of HPB and Transplant Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Ugo BoggiDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
Luca AldrighettiDivision of Hepatobiliary Surgery, IRCCS San Raffaele Hospital, Vita-Salute University, Milan, Italy.
Lucas McCormackTransplant Unit, Hospital Aleman de Buenos Aires, Buenos Aires, Argentina.
Roberto Hernandez-AlejandroDepartment of HPB and Transplant Surgery, University of Rochester, Rochester, NY.
Alejandro SerrabloHPB Surgical Division, Miguel Servet University Hospital, Zaragoza, Spain.
Christian TosoDivision of Abdominal and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland.
Akinobu TaketomiDepartment of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Jean GugenheimDepartment of Digestive Surgery and Liver Transplant Unit, University Côte d'Azur, CHU de Nice, Nice, France.
Jiahong DongHepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Faisal HanifDepartment of HPB and Liver Transplant, Bahria International Hospital Orchard, Lahore, Pakistan.
Joon Seong ParkDepartment of Surgery, Division of HBP Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
José M RamiaDepartment of Surgery, HPB and Transplant Unit, General Universitary Hospital Alicante and Health and Biomedical Research Institute of Alicante, Alicante, Spain.
Myron SchwartzDepartment of Surgery, Division of HPB Service, Icahn School of Medicine at Mount Sinai, New York, NY.
Diego RamischGeneral Surgery Department Liver, Pancreas and Intestinal Transplant Unit, Favaloro Foundation University Hospital, Buenos Aires, Argentina.
Michelle L De OliveiraSwiss HPB and Transplant Center Zurich, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Karl J OldhaferDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Asklepios Hospital Barmbek, Semmelweis University of Medicine, Asklepios Campus Hamburg, Hamburg, Germany.
Koo Jeong KangDivision of Hepatobiliary-Pancreatic Surgery, Department of Surgery, School of Medicine, Keimyung University, Dongsan Hospital, Daegu, Republic of Korea.
Matteo CesconHepato-biliary surgery and Transplant Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Peter LodgeDepartment of Transplantation and Hepatobiliary Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Inne H M Borel RinkesDepartment of Surgical Oncology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands.
Takehiro NojiDepartment of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
John-Edwin ThomsonHepatobiliary Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide & Hepatobiliary Unit, Department of Surgery, Flinders Medical Centre, Adelaide, Australia.
Su Kah GohHepatobiliary Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide & Hepatobiliary Unit, Department of Surgery, Flinders Medical Centre, Adelaide, Australia.
William C ChapmanDepartment of Surgery, Section of Abdominal Organ Transplant, Washington University School of Medicine, St Louis, MO.
Sean P ClearyDivision of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN.
Juan PekoljHepato-Pancreato-Biliary Surgery Section and Liver Transplant Unit, General Surgery Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Jean-Marc RegimbeauDepartment of Oncology and Digestive Surgery, CHU Amiens-Picardie, Amiens, France.
Olivier ScattonDepartment of Digestive, Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP Pitié-Salpêtrière, Sorbonne Université, Centre de Recherche de Saint-Antoine, Paris, France.
Stéphanie TruantDepartment of Digestive Surgery and Transplantation, CHU Lille, University Lille, Lille, France.
Hauke LangDepartment of General, Visceral and Transplantation Surgery, University Hospital of Mainz, Mainz, Germany.
David FuksDepartment of Hepatobiliary, Digestive and Endocrine Surgery, Cochin Hospital, Paris Cité University, Paris, France.
Philippe BachellierHepato-Pancreato-Biliary Surgery and Liver Transplantation, University Hospital, Strasbourg University, Strasbourg, France.
Masayuki OhtsukaDepartment of General Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan.
Irinel PopescuDepartment of Surgery and Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
Kiyoshi HasegawaHepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Mickaël LesurtelDepartment of HPB Surgery and Liver Transplantation, AP-HP Beaujon Hospital, University of Paris Cité, Clichy, France.
René AdamPaul Brousse Hospital, AP-HP, University Paris-Saclay, Villejuif, France.
Daniel CherquiPaul Brousse Hospital, AP-HP, University Paris-Saclay, Villejuif, France.
Katsuhiko UesakaDivision of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Karim BoudjemaDepartment of Hepatobiliary and Digestive Surgery, Rennes University Hospital, Rennes, France.
Hugo Pinto-MarquesHepato-Biliary-Pancreatic and Transplantation Centre, Curry Cabral Hospital, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.
Michał GrątDepartment of General, Transplant and Liver Surgery, Medical University Warsaw, Warsaw, Poland.
Henrik PetrowskySwiss HPB and Transplant Center Zurich, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Tomoki EbataDivision of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Andreas PrachaliasDepartment of Hepatobiliary and Pancreatic Surgery, King's College Hospital, London, UK.
Ricardo Robles-CamposClinic and University Virgen de la Arrixaca Hospital, IMIB, Murcia, Spain.
Pierre-Alain ClavienSwiss HPB and Transplant Center Zurich, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Assistance Publique – Hôpitaux de Paris · FRUniversity Hospital of Zurich · CHHokkaido University · JPHospital Italiano de Buenos Aires · ARKing's College Hospital · GBRoyal Adelaide Hospital · AUUniversity Medical Center Utrecht · NLAsklepios Klinik Barmbek · DEAzienda USL di Bologna · ITCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire de Lille · FRCentre Hospitalier Universitaire de Nice · FRChiba University · JPErasmus MC · NLFavaloro Foundation · ARGangnam Severance Hospital · KRHospital Alemán · ARHospital Curry Cabral · PTHospital General Universitario de Alicante Doctor Balmis · ESHospital Universitario Miguel Servet · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy for liver tumors of all dignities.
backgroundOutcomes after open major hepatectomies vary widely lacking reference values for comparisons among centers, indications, types of resections, and minimally invasive procedures.
methodsA standard benchmark methodology was used covering consecutive patients, who underwent open major anatomic hepatectomy from 44 high-volume liver centers from 5 continents over a 5-year period (2016-2020). Benchmark cases were low-risk non-cirrhotic patients without significant comorbidities treated in high-volume centers (≥30 major liver resections/year). Benchmark values were set at the 75th percentile of median values of all centers. Minimum follow-up period was 1 year in each patient.
resultsOf 8044 patients, 2908 (36%) qualified as benchmark (low-risk) cases. Benchmark cutoffs for all indications include R0 resection ≥78%; liver failure (grade B/C) ≤10%; bile leak (grade B/C) ≤18%; complications ≥grade 3 and CCI ® ≤46% and ≤9 at 3 months, respectively. Benchmark values differed significantly between malignant and benign conditions so that reference values must be adjusted accordingly. Extended right hepatectomy (H1, 4-8 or H4-8) disclosed a higher cutoff for liver failure, while extended left (H1-5,8 or H2-5,8) were associated with higher cutoffs for bile leaks, but had superior oncologic outcomes, when compared to formal left hepatectomy (H1-4 or H2-4). The minimal follow-up for a conclusive outcome evaluation following open anatomic major resection must be 3 months.
conclusionThese new benchmark cutoffs for open major hepatectomy provide a powerful tool to convincingly evaluate other approaches including parenchymal-sparing procedures, laparoscopic/robotic approaches, and alternative treatments, such as ablation therapy, irradiation, or novel chemotherapy regimens.
Indexed as
LaparoscopyLiver FailureLiver NeoplasmsBenchmarkingHepatectomyHumansLength of StayPostoperative ComplicationsRetrospective Studies
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