Evidence map›Paper›PMID 37465929›Full record

Observational studyPerfusion2024

Children with single ventricle heart disease have a greater increase in sRAGE after cardiopulmonary bypass.

Bonnie A Brooks, Pranava Sinha, Steven J Staffa, Marni B Jacobs, Robert J Freishtat, Jason T Patregnani

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Perfusion, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Bonnie A BrooksDivision of Pediatric Critical Care Medicine, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-5158-3953
Pranava SinhaDepartment of Pediatric Cardiac Surgery, M Health Fairview University of Minnesota, Minneapolis MN, USA.
Steven J StaffaDepartment of Anesthesiology, Critical Care and Pain Medicine, Harvard University, Boston Children's Hospital, Boston, MA, USA.
Marni B JacobsDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, CA, USA.
Robert J FreishtatCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.
Jason T PatregnaniDivision of Pediatric Critical Care Medicine, Maine Medical Center, Tufts University School of Medicine, Barbara Bush Children's Hospital, Portland, ME, USA.
Children's National · USBoston Children's Hospital · USTufts University · USUniversity of Minnesota · US

Funding

K12 Career Development Program: Omics of Pediatric Lung Diseases in DCK12HL119994 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI FREISHTAT, ROBERT J · 2013 to 2017
$1.3M
NHLBI NIH HHS K12 HL119994
6 · The paper itself

Abstract

introductionReducing cardiopulmonary bypass (CPB) induced inflammatory injury is a potentially important strategy for children undergoing multiple operations for single ventricle palliation. We sought to characterize the soluble receptor for advanced glycation end products (sRAGE), a protein involved in acute lung injury and inflammation, in pediatric patients with congenital heart disease and hypothesized that patients undergoing single ventricle palliation would have higher levels of sRAGE following bypass than those with biventricular physiologies.

methodsThis was a prospective, observational study of children undergoing CPB. Plasma samples were obtained before and after bypass. sRAGE levels were measured and compared between those with biventricular and single ventricle heart disease using descriptive statistics and multivariate analysis for risk factors for lung injury.

resultssRAGE levels were measured in 40 patients: 19 with biventricular and 21 with single ventricle heart disease. Children undergoing single ventricle palliation had a higher factor and percent increase in sRAGE levels when compared to patients with biventricular circulations (4.6 vs. 2.4,

conclusionsChildren with single ventricle physiology have greater increase in sRAGE following CPB as compared to children undergoing biventricular repair. Larger studies delineating the role of sRAGE in children undergoing single ventricle palliation may be beneficial in understanding how to prevent complications in this high-risk population.

Indexed as

Cardiopulmonary BypassReceptor for Advanced Glycation End ProductsChildChild, PreschoolFemaleHeart Defects, CongenitalHeart VentriclesHumansInfantMaleProspective StudiesReceptor for Advanced Glycation End Productsacute lung injuryacute respiratory distress syndromebiomarkercardiopulmonary bypasscongenital heart diseaseinflammationsingle ventricle

Identifiers

PMID37465929
PMCPMC11451074
OpenAlexW4384663255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.