Evidence map›Paper›PMID 37465688›Full record

Trial reportFrontiers in immunology2023

Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination.

Nicole L Messina, Mariana G Sperotto, Marco A M Puga, Patricia V da Silva, Roberto D de Oliveira, Cecilia L Moore, Laure F Pittet, Tenaya Jamieson, Margareth Dalcolmo, Glauce Dos Santos and 4 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Different Fc scaffolds enhance the breadth ofFrontiers in immunology · 2025
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Nicole L MessinaInfectious Diseases Group, Infection and Immunity Theme, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Mariana G SperottoSchool of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Marco A M PugaSchool of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Patricia V da SilvaSchool of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Roberto D de OliveiraState University of Mato Grosso do Sul, Dourados-Mato Grosso do Sul, Brazil.
Cecilia L MooreClinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Laure F PittetInfectious Diseases Group, Infection and Immunity Theme, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Tenaya JamiesonInfectious Diseases Group, Infection and Immunity Theme, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Margareth DalcolmoHelio Fraga Reference Center, Oswaldo Cruz Foundation Ministry of Health, Rio de Janeiro, Rio de Janeiro, Brazil.
Glauce Dos SantosNational School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.
Bruno JardimInstitute of Clinical Research Carlos Borborema, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
Marcus V G LacerdaInstitute of Clinical Research Carlos Borborema, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
Nigel CurtisInfectious Diseases Group, Infection and Immunity Theme, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Julio CrodaSchool of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Fundação Oswaldo Cruz · BRMurdoch Children's Research Institute · AUFundação de Medicina Tropical · BRFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul · BRRoyal Children's Hospital · AUUniversidade Federal da Grande Dourados · BRUniversidade Federal de Mato Grosso do Sul · BRUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses. We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil. As participants were randomised to BCG vaccination or placebo in the preceding 0-6 months as part of the BCG vaccination to reduce the impact of COVID-19 in healthcare workers (BRACE) trial, we also investigated the influence of recent BCG vaccination on antibody responses to these COVID-19 vaccines. Twenty-eight days after the second dose of each vaccine, ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac vaccination. Recent BCG vaccination did not impact IgG antibody responses to ChAdOx1-S or CoronaVac.

Indexed as

COVID-19COVID-19 VaccinesAntibody FormationBCG VaccineChAdOx1 nCoV-19HumansImmunoglobulin GVaccinationVaccines, InactivatedBCG VaccineChAdOx1 nCoV-19COVID-19 VaccinesImmunoglobulin Gsinovac COVID-19 vaccineVaccines, InactivatedantibodyBCGChAdOx1-SCoronaVacCOVID-19vaccine

Identifiers

PMID37465688
PMCPMC10352084
OpenAlexW4382984349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.