Evidence map›Paper›PMID 37465386›Full record

ArticleFrontiers in plant science2023

Changing biosynthesis of terpenoid percursors in rice through synthetic biology.

Orio Basallo, Lucia Perez, Abel Lucido, Albert Sorribas, Alberto Marin-Saguino, Ester Vilaprinyo, Laura Perez-Fons, Alfonso Albacete, Cristina Martínez-Andújar, Paul D Fraser and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Orio BasalloSystems Biology Group, Department Ciències Mèdiques Bàsiques, Faculty of Medicine, Universitat de Lleida, Lleida, Spain.
Lucia PerezApplied Plant Biotechnology Group, Department de Producció Vegetal I Ciència Florestal, Escola Tècnica Superior d'Enginyeria Agroalimentària i Forestal i de Veterinària (ETSEAFiV), Universitat de Lleida, Lleida, Spain.
Abel LucidoSystems Biology Group, Department Ciències Mèdiques Bàsiques, Faculty of Medicine, Universitat de Lleida, Lleida, Spain.
Albert SorribasSystems Biology Group, Department Ciències Mèdiques Bàsiques, Faculty of Medicine, Universitat de Lleida, Lleida, Spain.
Alberto Marin-SaguinoSystems Biology Group, Department Ciències Mèdiques Bàsiques, Faculty of Medicine, Universitat de Lleida, Lleida, Spain.
Ester VilaprinyoSystems Biology Group, Department Ciències Mèdiques Bàsiques, Faculty of Medicine, Universitat de Lleida, Lleida, Spain.
Laura Perez-FonsSchool of Biological Sciences, Royal Holloway University of London, Egham Hill, United Kingdom.
Alfonso AlbaceteDepartament of Plant Nutrition, Center of Edaphology and Applied Biology of the Segura (CEBAS), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Murcia, Murcia, Spain.
Cristina Martínez-AndújarDepartament of Plant Nutrition, Center of Edaphology and Applied Biology of the Segura (CEBAS), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Murcia, Murcia, Spain.
Paul D FraserSchool of Biological Sciences, Royal Holloway University of London, Egham Hill, United Kingdom.
Paul ChristouApplied Plant Biotechnology Group, Department de Producció Vegetal I Ciència Florestal, Escola Tècnica Superior d'Enginyeria Agroalimentària i Forestal i de Veterinària (ETSEAFiV), Universitat de Lleida, Lleida, Spain.
Teresa CapellApplied Plant Biotechnology Group, Department de Producció Vegetal I Ciència Florestal, Escola Tècnica Superior d'Enginyeria Agroalimentària i Forestal i de Veterinària (ETSEAFiV), Universitat de Lleida, Lleida, Spain.
Rui AlvesSystems Biology Group, Department Ciències Mèdiques Bàsiques, Faculty of Medicine, Universitat de Lleida, Lleida, Spain.
Instituto de Investigación Biomédica de Lleida · ESUniversitat de Lleida · ESCentro de Edafología y Biología Aplicada del Segura · ESRoyal Holloway University of London · GBInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many highly valued chemicals in the pharmaceutical, biotechnological, cosmetic, and biomedical industries belong to the terpenoid family. Biosynthesis of these chemicals relies on polymerization of Isopentenyl di-phosphate (IPP) and/or dimethylallyl diphosphate (DMAPP) monomers, which plants synthesize using two alternative pathways: a cytosolic mevalonic acid (MVA) pathway and a plastidic methyleritritol-4-phosphate (MEP) pathway. As such, developing plants for use as a platform to use IPP/DMAPP and produce high value terpenoids is an important biotechnological goal. Still, IPP/DMAPP are the precursors to many plant developmental hormones. This creates severe challenges in redirecting IPP/DMAPP towards production of non-cognate plant metabolites. A potential solution to this problem is increasing the IPP/DMAPP production flux

Indexed as

mathematical modellingMEP pathwaymetabolic engineeringmulti level modellingMVA (mevalonic acid) pathwayterpenoid synthetic biology

Identifiers

PMID37465386
PMCPMC10350630
OpenAlexW4382940654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.