Evidence map›Paper›PMID 37465366›Full record

ArticleFrontiers in molecular neuroscience2023

Fiberoptic hemodynamic spectroscopy reveals abnormal cerebrovascular reactivity in a freely moving mouse model of Alzheimer's disease.

Daniel S Gareau, Nicholas RochaKim, Arnab Choudhury, Michael Bamkole, Matija Snuderl, Julia Zou, Anna Yaroslavsky, Steven L Jacques, Sidney Strickland, James G Krueger and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Daniel S GareauLaboratory of Investigative Dermatology, The Rockefeller University, New York, NY, United States.
Nicholas RochaKimDepartment of Pharmacology, Physiology and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ, United States.
Arnab ChoudhuryDepartment of Pharmacology, Physiology and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ, United States.
Michael BamkoleDepartment of Pharmacology, Physiology and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ, United States.
Matija SnuderlDepartment of Pathology, NYU Langone Health and Grossman School of Medicine, New York, NY, United States.
Julia ZouLaboratory of Investigative Dermatology, The Rockefeller University, New York, NY, United States.
Anna YaroslavskyDepartment of Physics and Applied Physics, University of Massachusetts, Lowell, MA, United States.
Steven L JacquesDepartment of Bioengineering, University of Washington, Seattle, WA, United States.
Sidney StricklandLaboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, United States.
James G KruegerLaboratory of Investigative Dermatology, The Rockefeller University, New York, NY, United States.
Hyung Jin AhnDepartment of Pharmacology, Physiology and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ, United States.
Rockefeller University · USRutgers, The State University of New Jersey · USRutgers New Jersey Medical School · USUniversity of Massachusetts Lowell · USUniversity of Washington · US

Funding

Vascular contribution to white matter lesions and motor dysfunction in AD and ADRDRF1AG078245 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI AHN, HYUNG JIN, DYKE, JONATHAN PAUL · 2022 to 2025
$3.2M
Studying Pathogenic Mechanism of Hereditary Cerebral Amyloid AngiopathyR01NS104386 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI AHN, HYUNG JIN · 2018 to 2023
$2.1M
NINDS NIH HHS R01 NS104386
6 · The paper itself

Abstract

Many Alzheimer's disease (AD) patients suffer from altered cerebral blood flow and damaged cerebral vasculature. Cerebrovascular dysfunction could play an important role in this disease. However, the mechanism underlying a vascular contribution in AD is still unclear. Cerebrovascular reactivity (CVR) is a critical mechanism that maintains cerebral blood flow and brain homeostasis. Most current methods to analyze CVR require anesthesia which is known to hamper the investigation of molecular mechanisms underlying CVR. We therefore combined spectroscopy, spectral analysis software, and an implantable device to measure cerebral blood volume fraction (

Indexed as

Alzheimer’s diseasecerebral blood volumecerebrovascular reactivityfiberoptic spectroscopyhypercapnia

Identifiers

PMID37465366
PMCPMC10350529
OpenAlexW4382982212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.