Evidence map›Paper›PMID 37465302›Full record

ArticleACS medicinal chemistry letters2023

Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels.

Alessandro Farinato, Maria Maddalena Cavalluzzi, Concetta Altamura, Carmen Campanale, Paola Laghetti, Ilaria Saltarella, Pietro Delre, Arthur Barbault, Nancy Tarantino, Gualtiero Milani and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Alessandro FarinatoSection of Pharmacology, Department of Pharmacy - Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID https://orcid.org/0000-0002-2770-242X
Maria Maddalena CavalluzziSection of Medicinal Chemistry, Department of Pharmacy - Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID https://orcid.org/0000-0002-3402-8170
Concetta AltamuraSection of Pharmacology, Department of Precision and Regenerative Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Carmen CampanaleSection of Pharmacology, Department of Precision and Regenerative Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Paola LaghettiSection of Pharmacology, Department of Precision and Regenerative Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Ilaria SaltarellaSection of Pharmacology, Department of Precision and Regenerative Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Pietro DelreCNR - Institute of Crystallography, via Amendola 122/o, 70126 Bari, Italy.
Arthur BarbaultCNR - Institute of Crystallography, via Amendola 122/o, 70126 Bari, Italy.
Nancy TarantinoSection of Pharmacology, Department of Pharmacy - Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Gualtiero MilaniSection of Medicinal Chemistry, Department of Pharmacy - Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Natalie Paola RotondoSection of Medicinal Chemistry, Department of Pharmacy - Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Lorenzo Di Cesare MannelliDepartment NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, 50139 Florence, Italy.
Carla GhelardiniDepartment NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, 50139 Florence, Italy.
Sabata PiernoSection of Pharmacology, Department of Pharmacy - Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Giuseppe Felice MangiatordiCNR - Institute of Crystallography, via Amendola 122/o, 70126 Bari, Italy.ORCID https://orcid.org/0000-0003-4042-2841
Giovanni LentiniSection of Medicinal Chemistry, Department of Pharmacy - Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Jean-François DesaphySection of Pharmacology, Department of Precision and Regenerative Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
University of Bari Aldo Moro · ITInstitute of Crystallography · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several commercially available and newly synthesized riluzole analogs were evaluated in vitro as voltage-gated skeletal muscle sodium-channel blockers. Data obtained from the patch-clamp technique demonstrated that potency is well correlated with lipophilicity and the introduction of a protonatable amino function in the benzothiazole 2-position enhances the use-dependent behavior. The most interesting compound, the 2-piperazine analog of riluzole (

Identifiers

PMID37465302
PMCPMC10350938
OpenAlexW4381891650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.