ArticlePlastic and reconstructive surgery. Global open2023
Regenerative Peripheral Nerve Interface Surgery: Anatomic and Technical Guide.
Article in Plastic and reconstructive surgery. Global open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06754969 (Does RPNI Reduce Incidence of Neuroma Formation Following Sural Nerve Biopsy), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does RPNI Reduce Incidence of Neuroma Formation Following Sural Nerve Biopsy: a Pilot Study
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Prophylactic Regenerative Peripheral Nerve Interfaces for Prevention of Postamputation Pain: A Systematic Review and Meta-Analysis of Comparative Clinical Studies.Journal of clinical medicine · 2026Review
- Regenerative Peripheral Nerve Interface (RPNI) and vascularized Denervated Muscle Targets (VDMT): a preclinical rabbit model as a translational feasibility and methodological platform.Journal of translational medicine · 2026Article
- Outcomes Following Regenerative Peripheral Nerve Interface Surgery and Associations With Preoperative Mental Health: A Retrospective Analysis of Upper-Extremity Neuromas.Journal of hand surgery global online · 2026Article
- Understanding the role of diabetes mellitus on symptomatic neuroma development and identifying the ideal patient for prophylactic surgical management.Archives of orthopaedic and trauma surgery · 2026Review
- Regenerative peripheral nerve interface following forequarter amputation: a case report.Frontiers in surgery · 2026Article
- Outcomes of Ertl Osteomyoplasty Transtibial Amputation With Primary Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interface.Plastic and reconstructive surgery. Global open · 2025Article
- Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model.Journal of neuroengineering and rehabilitation · 2025Article
- Prevention of nerve growth and evoked pain with a nerve cap graft device.NPJ Regenerative medicine · 2025Article
- Regenerative Peripheral Nerve Interface Surgery to Treat Chronic Postamputation Pain: A Prospective Study in Major Lower Limb Amputation Patients.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Multimodal Approaches for Pain Management and Improving Functional Outcomes Following Amputation.Journal of orthopaedics and sports medicine · 2025Article
- Somatosensory restoration and neural control strategies in lower-limb prostheses.npj biomedical innovations · 2025Review
- Intercostal Regenerative Peripheral Nerve Interface for the Prevention of Neuroma-Associated Postbreast Surgery Pain Syndrome in Breast Reconstruction: A Proof-of-Concept Study.Aesthetic surgery journal. Open forum · 2025Article
- Phantom limb pain, traumatic neuroma, or nerve sheath tumor? Illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Novel Utilization of the Regenerative Peripheral Nerve Interface Technique after Unsuccessful Nerve Release for Bilateral Frontal Migraines.Plastic and reconstructive surgery. Global open · 2024Article
- Regenerative Peripheral Nerve Interface Surgery for the Management of Chronic Posttraumatic Neuropathic Pain.Seminars in plastic surgery · 2024Review
- Regenerative Peripheral Nerve Interfaces for the Management of Symptomatic Non-extremity Neuropathic Pain and Neuromas.Eplasty · 2024Article
- Volume loss during muscle reinnervation surgery is correlated with reduced CMAP amplitude but not reduced force output in a rat hindlimb model.Frontiers in physiology · 2024Article
- Combined TMR and RPNI in a vasculopathy patient: A case report.JPRAS open · 2023Article
- [Diagnostics and surgical treatment of painful neuromas].Der Nervenarzt · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerative peripheral nerve interface (RPNI) surgery has been demonstrated to be an effective tool as an interface for neuroprosthetics. Additionally, it has been shown to be a reproducible and reliable strategy for the active treatment and for prevention of neuromas. The purpose of this article is to provide a comprehensive review of RPNI surgery to demonstrate its simplicity and empower reconstructive surgeons to add this to their armamentarium. This article discusses the basic science of neuroma formation and prevention, as well as the theory of RPNI. An anatomic review and discussion of surgical technique for each level of amputation and considerations for other etiologies of traumatic neuromas are included. Lastly, the authors discuss the future of RPNI surgery and compare this with other active techniques for the treatment of neuromas.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.